A1 Journal article (refereed)
Versailles project on advanced materials and standards (VAMAS) interlaboratory study on measuring the number concentration of colloidal gold nanoparticles (2022)

Minelli, C., Wywijas, M., Bartczak, D., Cuello-Nuñez, S., Infante, H. G., Deumer, J., Gollwitzer, C., Krumrey, M., Murphy, K. E., Johnson, M. E., Montoro, B. A. R., Strenge, I. H., Faure, B., Høghøj, P., Tong, V., Burr, L., Norling, K., Höök, F., Roesslein, M., . . . Shard, A. G. (2022). Versailles project on advanced materials and standards (VAMAS) interlaboratory study on measuring the number concentration of colloidal gold nanoparticles. Nanoscale, 14(12), 4690-4704. https://doi.org/10.1039/d1nr07775a

JYU authors or editors

Publication details

All authors or editors: Minelli, Caterina; Wywijas, Magdalena; Bartczak, Dorota; Cuello-Nuñez, Susana; Infante, Heidi Goenaga; Deumer, Jerome; Gollwitzer, Christian; Krumrey, Michael; Murphy, Karen E.; Johnson, Monique E.; et al.

Journal or series: Nanoscale

ISSN: 2040-3364

eISSN: 2040-3372

Publication year: 2022

Volume: 14

Issue number: 12

Pages range: 4690-4704

Publisher: Royal Society of Chemistry (RSC)

Publication country: United Kingdom

Publication language: English

DOI: https://doi.org/10.1039/d1nr07775a

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/80158


We describe the outcome of a large international interlaboratory study of the measurement of particle number concentration of colloidal nanoparticles, project 10 of the technical working area 34, “Nanoparticle Populations” of the Versailles Project on Advanced Materials and Standards (VAMAS). A total of 50 laboratories delivered results for the number concentration of 30 nm gold colloidal nanoparticles measured using particle tracking analysis (PTA), single particle inductively coupled plasma mass spectrometry (spICP-MS), ultraviolet-visible (UV-Vis) light spectroscopy, centrifugal liquid sedimentation (CLS) and small angle X-ray scattering (SAXS). The study provides quantitative data to evaluate the repeatability of these methods and their reproducibility in the measurement of number concentration of model nanoparticle systems following a common measurement protocol. We find that the population-averaging methods of SAXS, CLS and UV-Vis have high measurement repeatability and reproducibility, with between-labs variability of 2.6%, 11% and 1.4% respectively. However, results may be significantly biased for reasons including inaccurate material properties whose values are used to compute the number concentration. Particle-counting method results are less reproducibile than population-averaging methods, with measured between-labs variability of 68% and 46% for PTA and spICP-MS respectively. This study provides the stakeholder community with important comparative data to underpin measurement reproducibility and method validation for number concentration of nanoparticles.

Keywords: colloids; nanoparticles; gold; concentration (chemical properties); measuring technology; laboratory technology

Free keywords: concentration; colloids; gold; nanoparticles

Contributing organizations

Ministry reporting: Yes

Reporting Year: 2022

Preliminary JUFO rating: 2

Last updated on 2022-20-09 at 14:13