A2 Review article, Literature review, Systematic review
Rhythmic Memory Consolidation in the Hippocampus (2022)

Nokia, M. S., & Penttonen, M. (2022). Rhythmic Memory Consolidation in the Hippocampus. Frontiers in Neural Circuits, 16, Article 885684. https://doi.org/10.3389/fncir.2022.885684

JYU authors or editors

Publication details

All authors or editors: Nokia, Miriam S.; Penttonen, Markku

Journal or series: Frontiers in Neural Circuits

eISSN: 1662-5110

Publication year: 2022

Publication date: 01/04/2022

Volume: 16

Article number: 885684

Publisher: Frontiers Media

Publication country: Switzerland

Publication language: English

DOI: https://doi.org/10.3389/fncir.2022.885684

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/80452

Additional information: Perspective article.

Abstract

Functions of the brain and body are oscillatory in nature and organized according to a logarithmic scale. Brain oscillations and bodily functions such as respiration and heartbeat appear nested within each other and coupled together either based on phase or based on phase and amplitude. This facilitates communication in wide-spread neuronal networks and probably also between the body and the brain. It is a widely accepted view, that nested electrophysiological brain oscillations involving the neocortex, thalamus, and the hippocampus form the basis of memory consolidation. This applies especially to declarative memories, that is, memories of life events, for example. Here, we present our view of hippocampal contribution to the process of memory consolidation based on the general ideas stated above and on some recent findings on the topic by us and by other research groups. We propose that in addition to the interplay between neocortical slow oscillations, spindles, and hippocampal sharp-wave ripples during sleep, there are also additional mechanisms available in the hippocampus to control memory consolidation: a rather non-oscillatory hippocampal electrophysiological phenomenon called the dentate spike might provide a means to not only consolidate but to also modify the neural representation of declarative memories. Further, we suggest that memory consolidation in the hippocampus might be in part paced by breathing. These considerations might open new possibilities for regulating memory consolidation in rest and sleep.

Keywords: memory (cognition); hippocampus; neural networks (biology); oscillations; sleep; respiration; electrophysiology

Free keywords: electrophysiology; respiration; brain oscillations; sleep; neuronal circuits

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Ministry reporting: Yes

Reporting Year: 2022

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