A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Gut Microbiota and Serum Metabolome in Elite Cross-Country Skiers : A Controlled Study (2022)

Hintikka, J. E., Munukka, E., Valtonen, M., Luoto, R., Ihalainen, J. K., Kallonen, T., Waris, M., Heinonen, O. J., Ruuskanen, O., & Pekkala, S. (2022). Gut Microbiota and Serum Metabolome in Elite Cross-Country Skiers : A Controlled Study. Metabolites, 12(4), Article 335. https://doi.org/10.3390/metabo12040335

JYU-tekijät tai -toimittajat

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Hintikka, Jukka E.; Munukka, Eveliina; Valtonen, Maarit; Luoto, Raakel; Ihalainen, Johanna K.; Kallonen, Teemu; Waris, Matti; Heinonen, Olli J.; Ruuskanen, Olli; Pekkala, Satu

Lehti tai sarja: Metabolites

eISSN: 2218-1989

Julkaisuvuosi: 2022

Ilmestymispäivä: 07.04.2022

Volyymi: 12

Lehden numero: 4

Artikkelinumero: 335

Kustantaja: MDPI AG

Julkaisumaa: Sveitsi

Julkaisun kieli: englanti

DOI: https://doi.org/10.3390/metabo12040335

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/80570

Tiivistelmä

Exercise has been shown to affect gut the microbiome and metabolic health, with athletes typically displaying a higher microbial diversity. However, research on the gut microbiota and systemic metabolism in elite athletes remains scarce. In this study, we compared the gut microbiota profiles and serum metabolome of national team cross-country skiers at the end of an exhausting training and competitive season to those of normally physically-active controls. The gut microbiota were analyzed using 16S rRNA amplicon sequencing. Serum metabolites were analyzed using nuclear magnetic resonance. Phylogenetic diversity and the abundance of several mucin-degrading gut microbial taxa, including Akkermansia, were lower in the athletes. The athletes had a healthier serum lipid profile than the controls, which was only partly explained by body mass index. Butyricicoccus associated positively with HDL cholesterol, HDL2 cholesterol and HDL particle size. The Ruminococcus torques group was less abundant in the athlete group and positively associated with total cholesterol and VLDL and LDL particles. We found the healthier lipid profile of elite athletes to co-occur with known health-beneficial gut microbes. Further studies should elucidate these links and whether athletes are prone to mucin depletion related microbial changes during the competitive season.

YSO-asiasanat: urheilijat; kestävyyslajit; hiihtäjät; suolistomikrobisto; aineenvaihdunta; rasva-aineenvaihdunta; lipidit

Vapaat asiasanat: winter games; athletes; exercise; microbiology; metabolomics; lipids

Liittyvät organisaatiot

Hankkeet, joissa julkaisu on tehty

OKM-raportointi: Kyllä

Raportointivuosi: 2022

JUFO-taso: 1