A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Pulmonary Asbestos Fiber Burden is Related to Patient Survival in Malignant Pleural Mesothelioma (2022)
Laaksonen, S., Kettunen, E., Sutinen, E., Ilonen, I., Vehmas, T., Törmäkangas, T., Räsänen, J., Wolff, H., & Myllärniemi, M. (2022). Pulmonary Asbestos Fiber Burden is Related to Patient Survival in Malignant Pleural Mesothelioma. Journal of Thoracic Oncology, 17(8), 1032-1041. https://doi.org/10.1016/j.jtho.2022.03.012
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Laaksonen, Sanna; Kettunen, Eeva; Sutinen, Eva; Ilonen, Ilkka; Vehmas, Tapio; Törmäkangas, Timo; Räsänen, Jari; Wolff, Henrik; Myllärniemi, Marjukka
Lehti tai sarja: Journal of Thoracic Oncology
ISSN: 1556-0864
eISSN: 1556-1380
Julkaisuvuosi: 2022
Volyymi: 17
Lehden numero: 8
Artikkelin sivunumerot: 1032-1041
Kustantaja: Elsevier
Julkaisumaa: Alankomaat
Julkaisun kieli: englanti
DOI: https://doi.org/10.1016/j.jtho.2022.03.012
Pysyvä verkko-osoite: https://doi.org/10.1016/j.jtho.2022.03.012
Julkaisun avoin saatavuus: Muulla tavalla avoin
Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava
Tiivistelmä
Malignant pleural mesothelioma (MPM) is associated with poor prognosis and is strongly associated with occupational asbestos exposure. Given the importance of asbestos exposure in MPM pathogenesis, we retrospectively analyzed the types and concentrations of asbestos fibers within the lung tissues of patients with MPM and investigated their effects on all-cause mortality.
Methods
We formed a national dataset of patients with MPM identified from the Finnish Cancer Registry and Statistics Finland. These data were merged with pulmonary asbestos fiber analysis results received from the Finnish Institute of Occupational Health.
Results
We identified 590 patients with MPM that underwent pulmonary asbestos fiber analysis. The median asbestos concentration within dry lung tissue was 3.20 million fibers/gram (f/g) (range: 0-1700 million f/g). Crocidolite and anthophyllite were the most prevalent asbestos fiber types detected in lung tissue. The multivariable risk of death analyses, where changes over time were accounted for, revealed that total asbestos fiber concentration was associated with increased mortality. However, no difference in mortality was noted between different fiber types.
Conclusion
Our study revealed that pulmonary fiber concentrations correlated with the manner of asbestos usage. Anthophyllite was identified as the sole fiber in a sizable proportion of cases, supporting its independent role in the pathogenesis of MPM. Our findings suggest that asbestos fiber burden, but not fiber type, may have an impact on the prognosis of MPM.
YSO-asiasanat: mesoteliooma; asbesti; kuidut; altistuminen; työperäinen altistus; kuolleisuus
Vapaat asiasanat: malignant pleural mesothelioma; pulmonary fiber analysis; asbestos fibers; mortality
Liittyvät organisaatiot
OKM-raportointi: Kyllä
Raportointivuosi: 2022
JUFO-taso: 2
