A1 Journal article (refereed)
Model Studies on a Diastereoselective Synthesis of the C(33)-C(37) Fragment of Amphotericin B (2003)


Karisalmi, K., Koskinen, A., Nissinen, M., & Rissanen, K. (2003). Model Studies on a Diastereoselective Synthesis of the C(33)-C(37) Fragment of Amphotericin B. Tetrahedron, 59(9), 1421-1427. https://doi.org/10.1016/S0040-4020(03)00070-X


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Publication details

All authors or editorsKarisalmi, Kaisa; Koskinen, Ari; Nissinen, Maija; Rissanen, Kari

Journal or seriesTetrahedron

ISSN0040-4020

eISSN1464-5416

Publication year2003

Volume59

Issue number9

Pages range1421-1427

PublisherElsevier

Publication countryUnited Kingdom

Publication languageEnglish

DOIhttps://doi.org/10.1016/S0040-4020(03)00070-X

Publication open accessNot open

Publication channel open access


Abstract

A new, short and highly diastereoselective synthetic route aiming at the C(33)–C(37) fragment of Amphotericin B has been developed. Studies with a model aldehyde (benzaldehyde) have given very promising results: the desired stereochemistry of all four stereocenters of the target molecule has been achieved with high diastereoselection. The stereochemistry of three key intermediates and the target segment has been confirmed by X-ray crystallography.


Free keywordssynteesikemia


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Last updated on 2023-14-12 at 17:00