A1 Journal article (refereed)
Model Studies on a Diastereoselective Synthesis of the C(33)-C(37) Fragment of Amphotericin B (2003)
Karisalmi, K., Koskinen, A., Nissinen, M., & Rissanen, K. (2003). Model Studies on a Diastereoselective Synthesis of the C(33)-C(37) Fragment of Amphotericin B. Tetrahedron, 59(9), 1421-1427. https://doi.org/10.1016/S0040-4020(03)00070-X
JYU authors or editors
Publication details
All authors or editors: Karisalmi, Kaisa; Koskinen, Ari; Nissinen, Maija; Rissanen, Kari
Journal or series: Tetrahedron
ISSN: 0040-4020
eISSN: 1464-5416
Publication year: 2003
Volume: 59
Issue number: 9
Pages range: 1421-1427
Publisher: Elsevier
Publication country: United Kingdom
Publication language: English
DOI: https://doi.org/10.1016/S0040-4020(03)00070-X
Publication open access: Not open
Publication channel open access:
Abstract
A new, short and highly diastereoselective synthetic route aiming at the C(33)–C(37) fragment of Amphotericin B has been developed. Studies with a model aldehyde (benzaldehyde) have given very promising results: the desired stereochemistry of all four stereocenters of the target molecule has been achieved with high diastereoselection. The stereochemistry of three key intermediates and the target segment has been confirmed by X-ray crystallography.
Free keywords: synteesikemia
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