A1 Journal article (refereed)
Cortical beta burst dynamics are altered in Parkinson's disease but normalized by deep brain stimulation (2022)

Pauls, K. A. M., Korsun, O., Nenonen, J., Nurminen, J., Liljeström, M., Kujala, J., Pekkonen, E., & Renvall, H. (2022). Cortical beta burst dynamics are altered in Parkinson's disease but normalized by deep brain stimulation. Neuroimage, 257, Article 119308. https://doi.org/10.1016/j.neuroimage.2022.119308

JYU authors or editors

Publication details

All authors or editors: Pauls, K. Amande M.; Korsun, Olesia; Nenonen, Jukka; Nurminen, Jussi; Liljeström, Mia; Kujala, Jan; Pekkonen, Eero; Renvall, Hanna

Journal or series: Neuroimage

ISSN: 1053-8119

eISSN: 1095-9572

Publication year: 2022

Publication date: 13/05/2022

Volume: 257

Article number: 119308

Publisher: Elsevier

Publication country: Netherlands

Publication language: English

DOI: https://doi.org/10.1016/j.neuroimage.2022.119308

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/81694

Abstract

Exaggerated subthalamic beta oscillatory activity and increased beta range cortico-subthalamic synchrony have crystallized as the electrophysiological hallmarks of Parkinson's disease. Beta oscillatory activity is not tonic but occurs in ‘bursts’ of transient amplitude increases. In Parkinson's disease, the characteristics of these bursts are altered especially in the basal ganglia. However, beta oscillatory dynamics at the cortical level and how they compare with healthy brain activity is less well studied. We used magnetoencephalography (MEG) to study sensorimotor cortical beta bursting and its modulation by subthalamic deep brain stimulation in Parkinson's disease patients and age-matched healthy controls. We show that the changes in beta bursting amplitude and duration typical of Parkinson's disease can also be observed in the sensorimotor cortex, and that they are modulated by chronic subthalamic deep brain stimulation, which, in turn, is reflected in improved motor function at the behavioural level. In addition to the changes in individual beta bursts, their timing relative to each other was altered in patients compared to controls: bursts were more clustered in untreated Parkinson's disease, occurring in ‘bursts of bursts’, and re-burst probability was higher for longer compared to shorter bursts. During active deep brain stimulation, the beta bursting in patients resembled healthy controls’ data. In summary, both individual bursts’ characteristics and burst patterning are affected in Parkinson's disease, and subthalamic deep brain stimulation normalizes some of these changes to resemble healthy controls’ beta bursting activity, suggesting a non-invasive biomarker for patient and treatment follow-up.

Keywords: neural networks (biology); oscillations; Parkinson's disease; deep brain stimulation; MEG

Free keywords: magnetoencephalography; beta burst; oscillatory activity; resting state

Contributing organizations

Ministry reporting: Yes

VIRTA submission year: 2022

JUFO rating: 2