A1 Journal article (refereed)
Synthesis, X-ray Structure, Antimicrobial and Anticancer Activity of a Novel [Ag(ethyl-3-quinolate)2(citrate)] Complex (2022)
Altowyan, M. S., El-Naggar, M. A., Abu-Youssef, M. A. M., Soliman, S. M., Haukka, M., Barakat, A., & Badr, A. M. A. (2022). Synthesis, X-ray Structure, Antimicrobial and Anticancer Activity of a Novel [Ag(ethyl-3-quinolate)2(citrate)] Complex. Crystals, 12(3), Article 356. https://doi.org/10.3390/cryst12030356
JYU authors or editors
Publication details
All authors or editors: Altowyan, Mezna Saleh; El-Naggar, Mostafa A.; Abu-Youssef, Morsy A. M.; Soliman, Saied M.; Haukka, Matti; Barakat, Assem; Badr, Ahmed M. A.
Journal or series: Crystals
eISSN: 2073-4352
Publication year: 2022
Publication date: 07/03/2022
Volume: 12
Issue number: 3
Article number: 356
Publisher: MDPI AG
Publication country: Switzerland
Publication language: English
DOI: https://doi.org/10.3390/cryst12030356
Publication open access: Openly available
Publication channel open access: Open Access channel
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/81266
Abstract
A novel Ag(I) citrate complex with ethyl-3-quinolate (Et3qu) was synthesized. Its structure was confirmed using X-ray single crystal to be [Ag(Et3qu)2(citrate)]. It crystallized in the Triclinic crystal system and P-1 space group with unit cell parameters of a = 8.6475(2) Å, b = 11.4426(3) Å, c = 15.2256(3) Å, α = 73.636(2)°, β = 79.692(2)° and γ = 86.832(2)°, while the unit cell volume was 1422.19(6) Å3. In the unit cell, there are two [Ag(Et3qu)2(citrate)] molecules and one unit as the asymmetric formula. The molecular structure comprised one Ag(I) coordinated with two Et3qu molecules via two almost equidistant Ag-N bonds and one citrate ion acting as a mono-negative monodentate ligand via a short Ag-O bond (2.5401(14) Å). Hence, Ag(I) is tri-coordinated and has a highly distorted triangular planar coordination geometry which is more like to be described as a slightly distorted T-shape. The supramolecular structure of the [Ag(Et3qu)2(citrate)] complex was analyzed using Hirshfeld calculations. The H···H (39.3–40.1%), O···H (33.2-34.0%), C···C (9.1–9.5%) and C···H (7.2–7.4%) contacts shared significantly in the packing of the studied Ag(I) complex. The antimicrobial and anticancer activities of the Ag(I) complex were investigated. The [Ag(Et3qu)2(citrate)] complex has broad-spectrum antimicrobial activity specifically against the fungus A. fumigatus. In addition, the IC50 values of 1.87 ± 0.09 µg/mL and 0.95 ± 0.06 µg/mL against the breast MCF-7 and lung A-549 cell lines, respectively, revealed the potent anticancer activity of the [Ag(Et3qu)2(citrate)] complex compared to the free Et3qu (IC50 = 30.64 ± 1.98 and 22.89 ± 1.48 µg/mL, respectively).
Keywords: coordination complexes; silver; bioactive compounds; antimicrobial compounds; chemical synthesis; x-ray crystallography
Free keywords: Hirshfeld; X-ray; antimicrobial; anticancer; Ag/quinoline/citrate complex
Contributing organizations
Ministry reporting: Yes
Reporting Year: 2022
JUFO rating: 1