A1 Journal article (refereed)
Reliable fluorescence technique to detect the antibiotic colistin, a possible environmental threat due to its overuse (2022)

Mandal, S., Dey Bhowmik, A., Mukhuty, A., Kundu, S., Truong, K.-N., Rissanen, K., Chattopadhyay, A., & Sahoo, P. (2022). Reliable fluorescence technique to detect the antibiotic colistin, a possible environmental threat due to its overuse. Scientific Reports, 12, Article 9307. https://doi.org/10.1038/s41598-022-13471-z

JYU authors or editors

Publication details

All authors or editors: Mandal, Saurodeep; Dey Bhowmik, Arpan; Mukhuty, Alpana; Kundu, Shampa; Truong, Khai-Nghi; Rissanen, Kari; Chattopadhyay, Ansuman; Sahoo, Prithidipa

Journal or series: Scientific Reports

eISSN: 2045-2322

Publication year: 2022

Publication date: 03/06/2022

Volume: 12

Article number: 9307

Publisher: Nature Publishing Group

Publication country: United Kingdom

Publication language: English

DOI: https://doi.org/10.1038/s41598-022-13471-z

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/82018

Abstract

Colistin, considered a drug of last resort as it is effective towards multidrug-resistant Gram-negative bacterial infections. Oral administration of colistin in the poultry industry is a common practice, not only to prevent and reduce bacterial infections, but also as a rapid-growth promoter. Long-term exposure to any antibiotic will eventually lead to the development of bacterial resistance towards all antibiotics through various mechanisms in the physiological system and environment. Chicken is the most consumed source of animal protein for humans throughout the world. In addition, the manure of poultry, containing traces of the used antibiotics, is being used in farming. Exposure to excess amounts of colistin causes a great concern not only to the humans but to the environment as a whole. In the present contribution, colistin has been detected in chicken hepatocyte cells through in vivo confocal microscopy. In addition, the amount of colistin in the chicken excrements has been estimated. A simple chemosensor NAF, a dye-based on napthaldehyde furfural, was developed for the detection of colistin, supplemented with experimental evidence and theoretical calculations.

Keywords: environmental chemistry; harmful substances; antibiotics; heterocyclic compounds; fluorescence

Contributing organizations

Ministry reporting: Yes

Reporting Year: 2022

JUFO rating: 1