A1 Journal article (refereed)
High Lipid Content of Prey Fish and n−3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon (Salmo salar) and Is Reflected in Hepatic Biochemical Indices (2022)

Keinänen, M., Nikonen, S., Käkelä, R., Ritvanen, T., Rokka, M., Myllylä, T., Pönni, J., & Vuorinen, P. J. (2022). High Lipid Content of Prey Fish and n−3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon (Salmo salar) and Is Reflected in Hepatic Biochemical Indices. Biomolecules, 12(4), Article 526. https://doi.org/10.3390/biom12040526

JYU authors or editors

Publication details

All authors or editors: Keinänen, Marja; Nikonen, Soili; Käkelä, Reijo; Ritvanen, Tiina; Rokka, Mervi; Myllylä, Timo; Pönni, Jukka; Vuorinen, Pekka J.

Journal or series: Biomolecules

eISSN: 2218-273X

Publication year: 2022

Publication date: 30/03/2022

Volume: 12

Issue number: 4

Article number: 526

Publisher: MDPI AG

Publication country: Switzerland

Publication language: English

DOI: https://doi.org/10.3390/biom12040526

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/81843

Abstract

Signs of impaired thiamine (vitamin B1) status in feeding-migrating Atlantic salmon (Salmo salar) were studied in three Baltic Sea areas, which differ in the proportion and nutritional composition of prey fish sprat (Sprattus sprattus) and herring (Clupea harengus). The concentration of n−3 polyunsaturated fatty acids (n−3 PUFAs) increased in salmon with dietary lipids and n−3 PUFAs, and the hepatic peroxidation product malondialdehyde (MDA) concentration increased exponentially with increasing n−3 PUFA and docosahexaenoic acid (DHA, 22:6n−3) concentration, whereas hepatic total thiamine concentration, a sensitive indicator of thiamine status, decreased with the increase in both body lipid and n−3 PUFA or DHA concentration. The hepatic glucose 6-phosphate dehydrogenase activity was suppressed by high dietary lipids. In salmon muscle and in prey fish, the proportion of thiamine pyrophosphate increased, and that of free thiamine decreased, with increasing body lipid content or PUFAs, or merely DHA. The thiamine status of salmon was impaired mainly due to the peroxidation of n−3 PUFAs, whereas lipids as a source of metabolic energy had less effect. Organochlorines or general oxidative stress did not affect the thiamine status. The amount of lipids, and, specifically, their long-chain n−3 PUFAs, are thus responsible for generating thiamine deficiency, and not a prey fish species per se.

Keywords: migratory fishes; Atlantic salmon; nutrition; nutritional deficiencies; thiamin; lipid metabolism; oxidative stress; lipids; malondialdehyde; Atlantic herring; sprat

Free keywords: Atlantic salmon Salmo salar; Baltic Sea; herring Clupea harengus; lipid peroxidation; M74 syndrome; malondialdehyde; polyunsaturated fatty acids; sprat Sprattus sprattus; thiamine; total lipids

Contributing organizations

Ministry reporting: Yes

Reporting Year: 2022

JUFO rating: 1