A1 Journal article (refereed)
Schizophrenia polygenic risk score and long-term success in the labour market : A cohort study (2022)

Viinikainen, J., Böckerman, P., Hakulinen, C., Kari, J., Lehtimäki, T., Raitakari, O., & Pehkonen, J. (2022). Schizophrenia polygenic risk score and long-term success in the labour market : A cohort study. Journal of Psychiatric Research, 151, 638-641. https://doi.org/10.1016/j.jpsychires.2022.05.041

JYU authors or editors

Publication details

All authors or editorsViinikainen, Jutta; Böckerman, Petri; Hakulinen, Christian; Kari, Jaana, T.; Lehtimäki, Terho; Raitakari, Olli, T.; Pehkonen, Jaakko

Journal or seriesJournal of Psychiatric Research



Publication year2022

Publication date26/05/2022


Pages range638-641


Publication countryUnited Kingdom

Publication languageEnglish


Publication open accessOpenly available

Publication channel open accessPartially open access channel

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/82236

Additional informationShort communication.


Employment is rare among people with a schizophrenia diagnosis. Meanwhile, a genetic liability for schizophrenia may hinder labour market performance. We studied how the polygenic risk score (PGS) for schizophrenia related to education and labour market outcomes. We found that a higher PGS was linked to lower educational levels and weaker labour market outcomes as well as a higher likelihood of receiving social income transfers, particularly among men. Assuming that the link is causal, our results indicate that individuals with schizophrenia or schizophrenia-related traits have a weakened ability to fully participate in the labour market, potentially reinforcing social exclusion.

Keywordshereditary diseasesschizophreniahereditary predispositionlevel of educationlabour statusaccess to employment

Free keywordsPolygenic risk score; Education; Earnings; Social income transfers

Contributing organizations

Ministry reportingYes

Reporting Year2022

JUFO rating1

Last updated on 2024-03-04 at 19:36