A1 Journal article (refereed)
Schizophrenia polygenic risk score and long-term success in the labour market : A cohort study (2022)

Viinikainen, J., Böckerman, P., Hakulinen, C., Kari, J., Lehtimäki, T., Raitakari, O., & Pehkonen, J. (2022). Schizophrenia polygenic risk score and long-term success in the labour market : A cohort study. Journal of Psychiatric Research, 151, 638-641. https://doi.org/10.1016/j.jpsychires.2022.05.041

JYU authors or editors

Publication details

All authors or editors: Viinikainen, Jutta; Böckerman, Petri; Hakulinen, Christian; Kari, Jaana, T.; Lehtimäki, Terho; Raitakari, Olli, T.; Pehkonen, Jaakko

Journal or series: Journal of Psychiatric Research

ISSN: 0022-3956

eISSN: 1879-1379

Publication year: 2022

Publication date: 26/05/2022

Volume: 151

Pages range: 638-641

Publisher: Elsevier

Publication country: United Kingdom

Publication language: English

DOI: https://doi.org/10.1016/j.jpsychires.2022.05.041

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/82236

Additional information: Short communication.


Employment is rare among people with a schizophrenia diagnosis. Meanwhile, a genetic liability for schizophrenia may hinder labour market performance. We studied how the polygenic risk score (PGS) for schizophrenia related to education and labour market outcomes. We found that a higher PGS was linked to lower educational levels and weaker labour market outcomes as well as a higher likelihood of receiving social income transfers, particularly among men. Assuming that the link is causal, our results indicate that individuals with schizophrenia or schizophrenia-related traits have a weakened ability to fully participate in the labour market, potentially reinforcing social exclusion.

Keywords: hereditary diseases; schizophrenia; hereditary predisposition; level of education; labour status; access to employment

Free keywords: Polygenic risk score; Education; Earnings; Social income transfers

Contributing organizations

Ministry reporting: Yes

Reporting Year: 2022

Preliminary JUFO rating: 1

Last updated on 2023-30-03 at 08:44