A1 Journal article (refereed)
Persulfate contribution to photolytic and pulsed corona discharge oxidation of metformin and tramadol in water (2022)

Nikitin, D., Kaur, B., Preis, S., & Dulova, N. (2022). Persulfate contribution to photolytic and pulsed corona discharge oxidation of metformin and tramadol in water. Process Safety and Environmental Protection, 165, 22-30. https://doi.org/10.1016/j.psep.2022.07.002

JYU authors or editors

Publication details

All authors or editorsNikitin, Dmitri; Kaur, Balpreet; Preis, Sergei; Dulova, Niina

Journal or seriesProcess Safety and Environmental Protection



Publication year2022

Publication date04/07/2022


Pages range22-30


Publication countryNetherlands

Publication languageEnglish


Publication open accessNot open

Publication channel open access


Degradation and mineralization of antidiabetic metformin (MTF) and opioid tramadol (TMD) in water were studied in UV photolytic oxidation and pulsed corona discharge (PCD) combined with extrinsic persulfate (PS) as UV/PS and PCD/PS systems. The effect of PS dose variation on the oxidation rate and efficiency was assessed. The UV/PS combination showed considerable effect in MTF and TMD removal, enhancing the removal of TOC up to 60–65% at maximum applied PS dose, thus providing the highest cost efficiency. As for the PCD/PS oxidation, the synergy was noticed for MTF, moderately increasing the oxidation rate and mineralization at somewhat increased expense. The PS addition to PCD treatment, however, demonstrated no effect on TMD oxidation. The highest energy efficiency in MTF and TMD degradation was thus showed by non-assisted PCD treatment with an energy yield at 90% conversion of the target compound of 5.6 and 13 g kW-1 h-1, respectively, confirming its practical applicability. The effective mineralization of the target compounds in persulfate photolysis makes it promising for use in advanced water purification. To assess the environmental safety of the studied oxidation processes, the acute toxicity of the treated MTF and TMD solutions to luminous bacteria (Vibrio fischeri) was examined.

Keywordsmedicinesresidueswater systemsoxidation (active)oxidation (passive)mineralisationdisintegrationdecomposition (chemistry)water purificationwater treatmentenergy efficiencycost effectivenessenvironmental safety

Free keywordsoxidation; pharmaceuticals; photolysis; peroxydisulfate; electric discharge: plasma

Contributing organizations

Ministry reportingYes

Reporting Year2022

JUFO rating1

Last updated on 2024-03-04 at 17:27