A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease (2022)


Cheng, R., Wang, L., Le, S., Yang, Y., Zhao, C., Zhang, X., Yang, X., Xu, T., Xu, L., Wiklund, P., Ge, J., Lu, D., Zhang, C., Chen, L., & Cheng, S. (2022). A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease. Nature Communications, 13, Article 2555. https://doi.org/10.1038/s41467-022-29968-0


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajatCheng, Runtan; Wang, Lu; Le, Shenglong; Yang, Yifan; Zhao, Can; Zhang, Xiangqi; Yang, Xin; Xu, Ting; Xu, Leiting; Wiklund, Petri; et al.

Lehti tai sarjaNature Communications

eISSN2041-1723

Julkaisuvuosi2022

Ilmestymispäivä10.05.2022

Volyymi13

Artikkelinumero2555

KustantajaNature Publishing Group

JulkaisumaaBritannia

Julkaisun kielienglanti

DOIhttps://doi.org/10.1038/s41467-022-29968-0

Linkki tutkimusaineistoonhttps://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA757939

Julkaisun avoin saatavuusAvoimesti saatavilla

Julkaisukanavan avoin saatavuusKokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX)https://jyx.jyu.fi/handle/123456789/82666

Julkaisu on rinnakkaistallennettuhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091228/


Tiivistelmä

Exercise and diet are treatments for nonalcoholic fatty liver disease (NAFLD) and prediabetes, however, how exercise and diet interventions impact gut microbiota in patients is incompletely understood. We previously reported a 8.6-month, four-arm (Aerobic exercise, n = 29; Diet, n = 28; Aerobic exercise + Diet, n = 29; No intervention, n = 29) randomized, singe blinded (for researchers), and controlled intervention in patients with NAFLD and prediabetes to assess the effect of interventions on the primary outcomes of liver fat content and glucose metabolism. Here we report the third primary outcome of the trial—gut microbiota composition—in participants who completed the trial (22 in Aerobic exercise, 22 in Diet, 23 in Aerobic exercise + Diet, 18 in No Intervention). We show that combined aerobic exercise and diet intervention are associated with diversified and stabilized keystone taxa, while exercise and diet interventions alone increase network connectivity and robustness between taxa. No adverse effects were observed with the interventions. In addition, in exploratory ad-hoc analyses we find that not all subjects responded to the intervention in a similar manner, when using differentially altered gut microbe amplicon sequence variants abundance to classify the responders and low/non-responders. A personalized gut microbial network at baseline could predict the individual responses in liver fat to exercise intervention. Our findings suggest an avenue for developing personalized intervention strategies for treatment of NAFLD based on host-gut microbiome ecosystem interactions, however, future studies with large sample size are needed to validate these discoveries. The Trial Registration Number is ISRCTN 42622771.


YSO-asiasanatei-alkoholiperäinen rasvamaksasairausliikuntahoitoravitsemushoitosuolistomikrobistointerventiotutkimussatunnaistetut vertailukokeet


Liittyvät organisaatiot


OKM-raportointiKyllä

Raportointivuosi2022

JUFO-taso3


Viimeisin päivitys 2024-26-03 klo 09:21