A1 Journal article (refereed)
A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease (2022)

Cheng, R., Wang, L., Le, S., Yang, Y., Zhao, C., Zhang, X., Yang, X., Xu, T., Xu, L., Wiklund, P., Ge, J., Lu, D., Zhang, C., Chen, L., & Cheng, S. (2022). A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease. Nature Communications, 13, Article 2555. https://doi.org/10.1038/s41467-022-29968-0

JYU authors or editors

Publication details

All authors or editors: Cheng, Runtan; Wang, Lu; Le, Shenglong; Yang, Yifan; Zhao, Can; Zhang, Xiangqi; Yang, Xin; Xu, Ting; Xu, Leiting; Wiklund, Petri; et al.

Journal or series: Nature Communications

eISSN: 2041-1723

Publication year: 2022

Publication date: 10/05/2022

Volume: 13

Article number: 2555

Publisher: Nature Publishing Group

Publication country: United Kingdom

Publication language: English

DOI: https://doi.org/10.1038/s41467-022-29968-0

Research data link: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA757939

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/82666

Publication is parallel published: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091228/

Abstract

Exercise and diet are treatments for nonalcoholic fatty liver disease (NAFLD) and prediabetes, however, how exercise and diet interventions impact gut microbiota in patients is incompletely understood. We previously reported a 8.6-month, four-arm (Aerobic exercise, n = 29; Diet, n = 28; Aerobic exercise + Diet, n = 29; No intervention, n = 29) randomized, singe blinded (for researchers), and controlled intervention in patients with NAFLD and prediabetes to assess the effect of interventions on the primary outcomes of liver fat content and glucose metabolism. Here we report the third primary outcome of the trial—gut microbiota composition—in participants who completed the trial (22 in Aerobic exercise, 22 in Diet, 23 in Aerobic exercise + Diet, 18 in No Intervention). We show that combined aerobic exercise and diet intervention are associated with diversified and stabilized keystone taxa, while exercise and diet interventions alone increase network connectivity and robustness between taxa. No adverse effects were observed with the interventions. In addition, in exploratory ad-hoc analyses we find that not all subjects responded to the intervention in a similar manner, when using differentially altered gut microbe amplicon sequence variants abundance to classify the responders and low/non-responders. A personalized gut microbial network at baseline could predict the individual responses in liver fat to exercise intervention. Our findings suggest an avenue for developing personalized intervention strategies for treatment of NAFLD based on host-gut microbiome ecosystem interactions, however, future studies with large sample size are needed to validate these discoveries. The Trial Registration Number is ISRCTN 42622771.

Keywords: non-alcoholic fatty liver disease; exercise therapy; diet therapy; gastrointestinal microbiota; intervention study; randomised controlled trials

Contributing organizations

Ministry reporting: Yes

Reporting Year: 2022

JUFO rating: 3