A1 Journal article (refereed)
More comprehensive proprioceptive stimulation of the hand amplifies its cortical processing (2022)

Hakonen, M., Nurmi, T., Vallinoja, J., Jaatela, J., & Piitulainen, H. (2022). More comprehensive proprioceptive stimulation of the hand amplifies its cortical processing. Journal of neurophysiology, 128(3), 568-581. https://doi.org/10.1152/jn.00485.2021

JYU authors or editors

Publication details

All authors or editors: Hakonen, Maria; Nurmi, Timo; Vallinoja, Jaakko; Jaatela, Julia; Piitulainen, Harri

Journal or series: Journal of neurophysiology

ISSN: 0022-3077

eISSN: 1522-1598

Publication year: 2022

Publication date: 20/07/2022

Volume: 128

Issue number: 3

Pages range: 568-581

Publisher: American Physiological Society

Publication country: United States

Publication language: English

DOI: https://doi.org/10.1152/jn.00485.2021

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/82641

Web address of parallel published publication (pre-print): https://www.biorxiv.org/content/10.1101/2021.02.24.432547v1

Abstract

Corticokinematic coherence (CKC) quantifies the phase coupling between limb kinematics and cortical neurophysiological signals reflecting proprioceptive feedback to the primary sensorimotor (SM1) cortex. We studied whether the CKC strength or cortical source location differs between proprioceptive stimulation (i.e., actuator-evoked movements) of right-hand digits (index, middle, ring and little). Twenty-one volunteers participated in magnetoencephalography measurements during which three conditions were tested: (1) simultaneous stimulation of all four fingers at the same frequency, (2) stimulation of each finger separately at the same frequency and (3) simultaneous stimulation of the fingers at finger-specific frequencies. CKC was computed between MEG responses and accelerations of the fingers recorded with three-axis accelerometers. CKC was stronger (p < 0.003) for the simultaneous (0.52 ± 0.02) than separate (0.45 ± 0.02) stimulation at the same frequency. Furthermore, CKC was weaker (p < 0.03) for the simultaneous stimulation at the finger-specific frequencies (0.38 ± 0.02) than for the separate stimulation. CKC source locations of the fingers were concentrated in the hand region of the SM1 cortex and did not follow consistent finger-specific somatotopic order. Our results indicate that that proprioceptive afference from the fingers is processed in partly overlapping cortical neuronal circuits, which was demonstrated by the modulation of the finger specific CKC strengths due to proprioceptive afference arising from simultaneous stimulation of the other fingers of the same hand as well as overlapping cortical source locations. Finally, comprehensive simultaneous proprioceptive stimulation of the hand would optimize functional cortical mapping to pinpoint the hand region, e.g., prior brain surgery.

Keywords: MEG; kinaesthesia; neurophysiology; cerebral cortex; hands; fingers

Free keywords: corticokinematic coherence; acceleration; magnetoencephalography; proprioception; sensorimotor cortex

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Ministry reporting: Yes

Reporting Year: 2022

JUFO rating: 2