A1 Journal article (refereed)
Accelerometer-Based Sedentary Time, Physical Activity, and Serum Metabolome in Young Men (2022)

Vaara, J. P., Kyröläinen, H., Vasankari, T., Kainulainen, H., Raitanen, J., & Kujala, U. M. (2022). Accelerometer-Based Sedentary Time, Physical Activity, and Serum Metabolome in Young Men. Metabolites, 12(8), 700. https://doi.org/10.3390/metabo12080700

JYU authors or editors

Publication details

All authors or editorsVaara, Jani P.; Kyröläinen, Heikki; Vasankari, Tommi; Kainulainen, Heikki; Raitanen, Jani; Kujala, Urho M.

Journal or seriesMetabolites


Publication year2022

Publication date27/07/2022


Issue number8

Pages range700

PublisherMDPI AG

Publication countrySwitzerland

Publication languageEnglish


Publication open accessOpenly available

Publication channel open accessOpen Access channel

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/82550


Physical activity (PA) has been shown to associate with many health benefits but studies with metabolome-wide associations with PA are still lacking. Metabolome studies may deepen the mechanistic understanding of PA on the metabolic pathways related to health outcomes. The aim of the present study was to study the association of accelerometer based sedentary time (SB) and PA with metabolome measures. SB and PA were measured by a hip-worn accelerometer in 314 young adult men (age: mean 28, standard deviation 7 years). Metabolome was analyzed from fasting serum samples consisting of 66 metabolome measures (nuclear magnetic resonance-based metabolomics). The associations were analyzed using a single and compositional approach with regression analysis. The compositional analysis revealed that 4 metabolome variables were significantly (γ: 0.32–0.44, p ≤ 0.002), and 13 variables with a trend towards significance (p < 0.05), associated with SB with varying metabolic pathways. Trends towards significant associations (p < 0.05) were observed with 5 variables with moderate-to-vigorous and 1 variable with light intensity PA with varying metabolic pathways. The present study revealed possible mechanistic pathways relevant for the interaction between especially SB but also PA of moderate-to-vigorous intensity with ketone bodies and amino acid concentration related to exercised-induced energy production and lipid metabolism.

Keywordsphysical trainingbody compositionmetabolismcardiovascular diseases

Free keywordsobjective physical activity; sedentary time; body composition; metabolomics; cardiovascular risk factors

Contributing organizations

Ministry reportingYes

Reporting Year2022

JUFO rating1

Last updated on 2024-03-04 at 19:17