A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Accelerometer-Based Sedentary Time, Physical Activity, and Serum Metabolome in Young Men (2022)


Vaara, J. P., Kyröläinen, H., Vasankari, T., Kainulainen, H., Raitanen, J., & Kujala, U. M. (2022). Accelerometer-Based Sedentary Time, Physical Activity, and Serum Metabolome in Young Men. Metabolites, 12(8), 700. https://doi.org/10.3390/metabo12080700


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajatVaara, Jani P.; Kyröläinen, Heikki; Vasankari, Tommi; Kainulainen, Heikki; Raitanen, Jani; Kujala, Urho M.

Lehti tai sarjaMetabolites

eISSN2218-1989

Julkaisuvuosi2022

Ilmestymispäivä27.07.2022

Volyymi12

Lehden numero8

Artikkelin sivunumerot700

KustantajaMDPI AG

JulkaisumaaSveitsi

Julkaisun kielienglanti

DOIhttps://doi.org/10.3390/metabo12080700

Julkaisun avoin saatavuusAvoimesti saatavilla

Julkaisukanavan avoin saatavuusKokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX)https://jyx.jyu.fi/handle/123456789/82550


Tiivistelmä

Physical activity (PA) has been shown to associate with many health benefits but studies with metabolome-wide associations with PA are still lacking. Metabolome studies may deepen the mechanistic understanding of PA on the metabolic pathways related to health outcomes. The aim of the present study was to study the association of accelerometer based sedentary time (SB) and PA with metabolome measures. SB and PA were measured by a hip-worn accelerometer in 314 young adult men (age: mean 28, standard deviation 7 years). Metabolome was analyzed from fasting serum samples consisting of 66 metabolome measures (nuclear magnetic resonance-based metabolomics). The associations were analyzed using a single and compositional approach with regression analysis. The compositional analysis revealed that 4 metabolome variables were significantly (γ: 0.32–0.44, p ≤ 0.002), and 13 variables with a trend towards significance (p < 0.05), associated with SB with varying metabolic pathways. Trends towards significant associations (p < 0.05) were observed with 5 variables with moderate-to-vigorous and 1 variable with light intensity PA with varying metabolic pathways. The present study revealed possible mechanistic pathways relevant for the interaction between especially SB but also PA of moderate-to-vigorous intensity with ketone bodies and amino acid concentration related to exercised-induced energy production and lipid metabolism.


YSO-asiasanatliikuntakehonkoostumusaineenvaihduntasydän- ja verisuonitaudit

Vapaat asiasanatobjective physical activity; sedentary time; body composition; metabolomics; cardiovascular risk factors


Liittyvät organisaatiot


OKM-raportointiKyllä

Raportointivuosi2022

JUFO-taso1


Viimeisin päivitys 2024-15-06 klo 00:27