A2 Katsausartikkeli tieteellisessä aikausilehdessä
Nuclear entry and egress of parvoviruses (2022)
Mattola, S., Aho, V., Bustamante‐Jaramillo, L. F., Pizzioli, E., Kann, M., & Vihinen‐Ranta, M. (2022). Nuclear entry and egress of parvoviruses. Molecular Microbiology, 118(4), 295-308. https://doi.org/10.1111/mmi.14974
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Mattola, Salla; Aho, Vesa; Bustamante‐Jaramillo, Luisa F.; Pizzioli, Edoardo; Kann, Michael; Vihinen‐Ranta, Maija
Lehti tai sarja: Molecular Microbiology
ISSN: 0950-382X
eISSN: 1365-2958
Julkaisuvuosi: 2022
Ilmestymispäivä: 16.08.2022
Volyymi: 118
Lehden numero: 4
Artikkelin sivunumerot: 295-308
Kustantaja: Wiley
Julkaisumaa: Britannia
Julkaisun kieli: englanti
DOI: https://doi.org/10.1111/mmi.14974
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/82782
Tiivistelmä
Parvoviruses are small non-enveloped single-stranded DNA viruses, which depend on host cell nuclear transcriptional and replication machinery. After endosomal exposure of nuclear localization sequence and a phospholipase A2 domain on the capsid surface, and escape into the cytosol, parvovirus capsids enter the nucleus. Due to the small capsid diameter of 18–26 nm, intact capsids can potentially pass into the nucleus through nuclear pore complexes (NPCs). This might be facilitated by active nuclear import, but capsids may also follow an alternative entry pathway that includes activation of mitotic factors and local transient disruption of the nuclear envelope. The nuclear entry is followed by currently undefined events of viral genome uncoating. After genome release, viral replication compartments are initiated and infection proceeds. Parvoviral genomes replicate during cellular S phase followed by nuclear capsid assembly during virus-induced S/G2 cell cycle arrest. Nuclear egress of capsids occurs upon nuclear envelope degradation during apoptosis and cell lysis. An alternative pathway for nuclear export has been described using active transport through the NPC mediated by the chromosome region maintenance 1 protein, CRM1, which is enhanced by phosphorylation of the N-terminal domain of VP2. However, other alternative but not yet uncharacterized nuclear export pathways cannot be excluded.
YSO-asiasanat: virukset; parvovirukset; kapsidi; infektiot; isäntäsolut; tuma
Vapaat asiasanat: parvoviruses; nucleus; import and export; nuclear envelope; nuclear pore complexes
Liittyvät organisaatiot
Hankkeet, joissa julkaisu on tehty
- Herpesviruksen kapsidien ja lähetti-RNA:n uloskuljetus tumasta
- Vihinen-Ranta, Maija
- Suomen Akatemia
OKM-raportointi: Kyllä
VIRTA-lähetysvuosi: 2022
JUFO-taso: 2