A2 Katsausartikkeli tieteellisessä aikausilehdessä
Nuclear entry and egress of parvoviruses (2022)


Mattola, S., Aho, V., Bustamante‐Jaramillo, L. F., Pizzioli, E., Kann, M., & Vihinen‐Ranta, M. (2022). Nuclear entry and egress of parvoviruses. Molecular Microbiology, 118(4), 295-308. https://doi.org/10.1111/mmi.14974


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajatMattola, Salla; Aho, Vesa; Bustamante‐Jaramillo, Luisa F.; Pizzioli, Edoardo; Kann, Michael; Vihinen‐Ranta, Maija

Lehti tai sarjaMolecular Microbiology

ISSN0950-382X

eISSN1365-2958

Julkaisuvuosi2022

Ilmestymispäivä16.08.2022

Volyymi118

Lehden numero4

Artikkelin sivunumerot295-308

KustantajaWiley

JulkaisumaaBritannia

Julkaisun kielienglanti

DOIhttps://doi.org/10.1111/mmi.14974

Julkaisun avoin saatavuusAvoimesti saatavilla

Julkaisukanavan avoin saatavuusOsittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX)https://jyx.jyu.fi/handle/123456789/82782


Tiivistelmä

Parvoviruses are small non-enveloped single-stranded DNA viruses, which depend on host cell nuclear transcriptional and replication machinery. After endosomal exposure of nuclear localization sequence and a phospholipase A2 domain on the capsid surface, and escape into the cytosol, parvovirus capsids enter the nucleus. Due to the small capsid diameter of 18–26 nm, intact capsids can potentially pass into the nucleus through nuclear pore complexes (NPCs). This might be facilitated by active nuclear import, but capsids may also follow an alternative entry pathway that includes activation of mitotic factors and local transient disruption of the nuclear envelope. The nuclear entry is followed by currently undefined events of viral genome uncoating. After genome release, viral replication compartments are initiated and infection proceeds. Parvoviral genomes replicate during cellular S phase followed by nuclear capsid assembly during virus-induced S/G2 cell cycle arrest. Nuclear egress of capsids occurs upon nuclear envelope degradation during apoptosis and cell lysis. An alternative pathway for nuclear export has been described using active transport through the NPC mediated by the chromosome region maintenance 1 protein, CRM1, which is enhanced by phosphorylation of the N-terminal domain of VP2. However, other alternative but not yet uncharacterized nuclear export pathways cannot be excluded.


YSO-asiasanatviruksetparvoviruksetkapsidiinfektiotisäntäsoluttuma

Vapaat asiasanatparvoviruses; nucleus; import and export; nuclear envelope; nuclear pore complexes


Liittyvät organisaatiot


Hankkeet, joissa julkaisu on tehty


OKM-raportointiKyllä

VIRTA-lähetysvuosi2022

JUFO-taso2


Viimeisin päivitys 2024-12-10 klo 14:45