A2 Review article, Literature review, Systematic review
Nuclear entry and egress of parvoviruses (2022)

Mattola, S., Aho, V., Bustamante‐Jaramillo, L. F., Pizzioli, E., Kann, M., & Vihinen‐Ranta, M. (2022). Nuclear entry and egress of parvoviruses. Molecular Microbiology, 118(4), 295-308. https://doi.org/10.1111/mmi.14974

JYU authors or editors

Publication details

All authors or editors: Mattola, Salla; Aho, Vesa; Bustamante‐Jaramillo, Luisa F.; Pizzioli, Edoardo; Kann, Michael; Vihinen‐Ranta, Maija

Journal or series: Molecular Microbiology

ISSN: 0950-382X

eISSN: 1365-2958

Publication year: 2022

Publication date: 16/08/2022

Volume: 118

Issue number: 4

Pages range: 295-308

Publisher: Wiley

Publication country: United Kingdom

Publication language: English

DOI: https://doi.org/10.1111/mmi.14974

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/82782

Abstract

Parvoviruses are small non-enveloped single-stranded DNA viruses, which depend on host cell nuclear transcriptional and replication machinery. After endosomal exposure of nuclear localization sequence and a phospholipase A2 domain on the capsid surface, and escape into the cytosol, parvovirus capsids enter the nucleus. Due to the small capsid diameter of 18–26 nm, intact capsids can potentially pass into the nucleus through nuclear pore complexes (NPCs). This might be facilitated by active nuclear import, but capsids may also follow an alternative entry pathway that includes activation of mitotic factors and local transient disruption of the nuclear envelope. The nuclear entry is followed by currently undefined events of viral genome uncoating. After genome release, viral replication compartments are initiated and infection proceeds. Parvoviral genomes replicate during cellular S phase followed by nuclear capsid assembly during virus-induced S/G2 cell cycle arrest. Nuclear egress of capsids occurs upon nuclear envelope degradation during apoptosis and cell lysis. An alternative pathway for nuclear export has been described using active transport through the NPC mediated by the chromosome region maintenance 1 protein, CRM1, which is enhanced by phosphorylation of the N-terminal domain of VP2. However, other alternative but not yet uncharacterized nuclear export pathways cannot be excluded.

Keywords: viruses; parvoviruses; capsid; infections; host cells; cell nucleus

Free keywords: parvoviruses; nucleus; import and export; nuclear envelope; nuclear pore complexes

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Related projects

Ministry reporting: Yes

VIRTA submission year: 2022

JUFO rating: 2