A1 Journal article (refereed)
1H NMR Urinary Metabolomic Analysis in Older Adults after Hip Fracture Surgery May Provide Valuable Information for Patient Profiling : A Preliminary Investigation (2022)

Douzi, W., Bon, D., Suikkanen, S., Soukkio, P., Boildieu, N., Nenonen, A., Hupli, M., Kukkonen-Harjula, K., & Dugué, B. (2022). 1H NMR Urinary Metabolomic Analysis in Older Adults after Hip Fracture Surgery May Provide Valuable Information for Patient Profiling : A Preliminary Investigation. Metabolites, 12(8), Article 744. https://doi.org/10.3390/metabo12080744

JYU authors or editors

Publication details

All authors or editors: Douzi, Wafa; Bon, Delphine; Suikkanen, Sara; Soukkio, Paula; Boildieu, Nadège; Nenonen, Arja; Hupli, Markku; Kukkonen-Harjula, Katriina; Dugué, Benoit

Journal or series: Metabolites

eISSN: 2218-1989

Publication year: 2022

Publication date: 12/08/2022

Volume: 12

Issue number: 8

Article number: 744

Publisher: MDPI AG

Publication country: Switzerland

Publication language: English

DOI: https://doi.org/10.3390/metabo12080744

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/82753

Additional information: This article belongs to the Special Issue "The Metabolic Adaptations in Non-pharmacological Interventions"

Abstract

In these times of precision and personalized medicine, profiling patients to identify their needs is crucial to providing the best and most cost-effective treatment. In this study, we used urine metabolomics to explore the characterization of older adults with hip fractures and to explore the forecasting of patient outcomes. Overnight urine specimens were collected from 33 patients (mean age 80 ± 8 years) after hip fracture surgery during their stay at a rehabilitation hospital. The specimens were analyzed with 1H NMR spectroscopy. We performed a metabolomics study regarding assessments of frailty status, Functional Independence Measure (FIM), and Short Physical Performance Battery (SPPB). The main metabolic variations concerned 10 identified metabolites: paracetamol derivatives (4 peaks: 2.15 ppm; 2.16 ppm; 7.13 ppm and 7.15 ppm); hippuric acid; acetate; acetone; dimethylamine; glycine; alanine; lactate; valine; TMAO. At baseline, the urinary levels of these metabolites were significantly higher (i) in frail compared with non-frail patients, (ii) in persons with poorer FIM scores, and (iii) in persons with poorer compared SPPB scores. Our findings suggested that patients with increased levels of urine metabolites associated with metabolic, inflammatory, and renal disorders presented clear signs of frailty, impaired functional independence, and poor physical performance. Metabolomics could be a valuable tool to further characterize older adults, especially after major medical events.

Keywords: hip; fractures; surgical treatment; older people; performance (capacity); physical functioning; Functional Independence Measure; metabolic products; urine; NMR spectroscopy

Free keywords: hip fracture; frailty; functioning; metabolomics; nuclear magnetic resonance spectroscopy

Contributing organizations

Ministry reporting: Yes

Reporting Year: 2022

JUFO rating: 1