A1 Journal article (refereed)
Modified ent-Abietane Diterpenoids from the Leaves of Suregada zanzibariensis (2022)

Kalenga, T. M., Mollel, J. T., Said, J., Orthaber, A., Ward, J. S., Atilaw, Y., Umereweneza, D., Ndoile, M. M., Munissi, J. J. E., Rissanen, K., Trybala, E., Bergström, T., Nyandoro, S. S., & Erdelyi, M. (2022). Modified ent-Abietane Diterpenoids from the Leaves of Suregada zanzibariensis. Journal of Natural Products, 85(9), 2135-2141. https://doi.org/10.1021/acs.jnatprod.2c00147

JYU authors or editors

Publication details

All authors or editors: Kalenga, Thobias M.; Mollel, Jackson T.; Said, Joanna; Orthaber, Andreas; Ward, Jas S.; Atilaw, Yoseph; Umereweneza, Daniel; Ndoile, Monica M.; Munissi, Joan J. E.; Rissanen, Kari; et al.

Journal or series: Journal of Natural Products

ISSN: 0163-3864

eISSN: 1520-6025

Publication year: 2022

Publication date: 08/09/2022

Volume: 85

Issue number: 9

Pages range: 2135-2141

Publisher: American Chemical Society (ACS)

Publication country: United States

Publication language: English

DOI: https://doi.org/10.1021/acs.jnatprod.2c00147

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/83240

Abstract

The leaf extract of Suregada zanzibariensis gave two new modified ent-abietane diterpenoids, zanzibariolides A (1) and B (2), and two known triterpenoids, simiarenol (3) and β-amyrin (4). The structures of the isolated compounds were elucidated based on NMR and MS data analysis. Single-crystal X-ray diffraction was used to establish the absolute configurations of compounds 1 and 2. The crude leaf extract inhibited the infectivity of herpes simplex virus 2 (HSV-2, IC50 11.5 μg/mL) and showed toxicity on African green monkey kidney (GMK AH1) cells at CC50 52 μg/mL. The isolated compounds 1–3 showed no anti-HSV-2 activity and exhibited insignificant toxicity against GMK AH1 cells at ≥100 μM.

Keywords: naturally occurring substances; terpenes; bioactive compounds; inhibitors; toxicity; Euphorbiaceae

Contributing organizations

Ministry reporting: Yes

Reporting Year: 2022

JUFO rating: 1