A1 Journal article (refereed)
Modified ent-Abietane Diterpenoids from the Leaves of Suregada zanzibariensis (2022)


Kalenga, T. M., Mollel, J. T., Said, J., Orthaber, A., Ward, J. S., Atilaw, Y., Umereweneza, D., Ndoile, M. M., Munissi, J. J. E., Rissanen, K., Trybala, E., Bergström, T., Nyandoro, S. S., & Erdelyi, M. (2022). Modified ent-Abietane Diterpenoids from the Leaves of Suregada zanzibariensis. Journal of Natural Products, 85(9), 2135-2141. https://doi.org/10.1021/acs.jnatprod.2c00147


JYU authors or editors


Publication details

All authors or editorsKalenga, Thobias M.; Mollel, Jackson T.; Said, Joanna; Orthaber, Andreas; Ward, Jas S.; Atilaw, Yoseph; Umereweneza, Daniel; Ndoile, Monica M.; Munissi, Joan J. E.; Rissanen, Kari; et al.

Journal or seriesJournal of Natural Products

ISSN0163-3864

eISSN1520-6025

Publication year2022

Publication date08/09/2022

Volume85

Issue number9

Pages range2135-2141

PublisherAmerican Chemical Society (ACS)

Publication countryUnited States

Publication languageEnglish

DOIhttps://doi.org/10.1021/acs.jnatprod.2c00147

Publication open accessOpenly available

Publication channel open accessPartially open access channel

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/83240


Abstract

The leaf extract of Suregada zanzibariensis gave two new modified ent-abietane diterpenoids, zanzibariolides A (1) and B (2), and two known triterpenoids, simiarenol (3) and β-amyrin (4). The structures of the isolated compounds were elucidated based on NMR and MS data analysis. Single-crystal X-ray diffraction was used to establish the absolute configurations of compounds 1 and 2. The crude leaf extract inhibited the infectivity of herpes simplex virus 2 (HSV-2, IC50 11.5 μg/mL) and showed toxicity on African green monkey kidney (GMK AH1) cells at CC50 52 μg/mL. The isolated compounds 1–3 showed no anti-HSV-2 activity and exhibited insignificant toxicity against GMK AH1 cells at ≥100 μM.


Keywordsnaturally occurring substancesterpenesbioactive compoundsinhibitorstoxicityEuphorbiaceae


Contributing organizations


Ministry reportingYes

VIRTA submission year2022

JUFO rating1


Last updated on 2024-12-10 at 14:15