A1 Journal article (refereed)
Modified ent-Abietane Diterpenoids from the Leaves of Suregada zanzibariensis (2022)
Kalenga, T. M., Mollel, J. T., Said, J., Orthaber, A., Ward, J. S., Atilaw, Y., Umereweneza, D., Ndoile, M. M., Munissi, J. J. E., Rissanen, K., Trybala, E., Bergström, T., Nyandoro, S. S., & Erdelyi, M. (2022). Modified ent-Abietane Diterpenoids from the Leaves of Suregada zanzibariensis. Journal of Natural Products, 85(9), 2135-2141. https://doi.org/10.1021/acs.jnatprod.2c00147
JYU authors or editors
Publication details
All authors or editors: Kalenga, Thobias M.; Mollel, Jackson T.; Said, Joanna; Orthaber, Andreas; Ward, Jas S.; Atilaw, Yoseph; Umereweneza, Daniel; Ndoile, Monica M.; Munissi, Joan J. E.; Rissanen, Kari; et al.
Journal or series: Journal of Natural Products
ISSN: 0163-3864
eISSN: 1520-6025
Publication year: 2022
Publication date: 08/09/2022
Volume: 85
Issue number: 9
Pages range: 2135-2141
Publisher: American Chemical Society (ACS)
Publication country: United States
Publication language: English
DOI: https://doi.org/10.1021/acs.jnatprod.2c00147
Publication open access: Openly available
Publication channel open access: Partially open access channel
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/83240
Abstract
The leaf extract of Suregada zanzibariensis gave two new modified ent-abietane diterpenoids, zanzibariolides A (1) and B (2), and two known triterpenoids, simiarenol (3) and β-amyrin (4). The structures of the isolated compounds were elucidated based on NMR and MS data analysis. Single-crystal X-ray diffraction was used to establish the absolute configurations of compounds 1 and 2. The crude leaf extract inhibited the infectivity of herpes simplex virus 2 (HSV-2, IC50 11.5 μg/mL) and showed toxicity on African green monkey kidney (GMK AH1) cells at CC50 52 μg/mL. The isolated compounds 1–3 showed no anti-HSV-2 activity and exhibited insignificant toxicity against GMK AH1 cells at ≥100 μM.
Keywords: naturally occurring substances; terpenes; bioactive compounds; inhibitors; toxicity; Euphorbiaceae
Contributing organizations
Ministry reporting: Yes
VIRTA submission year: 2022
JUFO rating: 1