A1 Journal article (refereed)
Probing the self-assembly and anti-glioblastoma efficacy of a cinnamoyl-capped dipeptide hydrogelator (2022)

Sitsanidis, E. D., Kasapidou, P. M., Hiscock, J. R., Gubala, V., Castel, H., Popoola, P. I. A., Hall, A. J., & Edwards, A.A. (2022). Probing the self-assembly and anti-glioblastoma efficacy of a cinnamoyl-capped dipeptide hydrogelator. Organic and Biomolecular Chemistry, 20(37), 7458-7466. https://doi.org/10.1039/d2ob01339h

JYU authors or editors

Publication details

All authors or editors: Sitsanidis, E. D.; Kasapidou, P. M.; Hiscock, J. R.; Gubala, V.; Castel, H.; Popoola, P. I. A.; Hall, A. J.; Edwards, A. A.

Journal or series: Organic and Biomolecular Chemistry

ISSN: 1477-0520

eISSN: 1477-0539

Publication year: 2022

Publication date: 12/09/2022

Volume: 20

Issue number: 37

Pages range: 7458-7466

Publisher: Royal Society of Chemistry (RSC)

Publication country: United Kingdom

Publication language: English

DOI: https://doi.org/10.1039/d2ob01339h

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/83234

Abstract

Herein, we introduce the first diphenylalanine dipeptide hydrogelator capped with the cinnamoyl functional group (Cin-L-F-L-F). We evaluate the effects of the cinnamoyl moiety on molecular self-assembly events and resultant physical properties of the hydrogel formed. In addition, we report our preliminary results of this dipeptide's cytotoxicity against glioblastoma (GBM) cancer cells.

Keywords: organic compounds; gels; biological activity; cancer cells; glioblastoma

Contributing organizations

Ministry reporting: Yes

VIRTA submission year: 2022

JUFO rating: 1