A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Hippocampal responses to electrical stimulation of the major input pathways are modulated by dentate spikes (2022)

Lehtonen, S., Waselius, T., Penttonen, M., & Nokia, M. S. (2022). Hippocampal responses to electrical stimulation of the major input pathways are modulated by dentate spikes. Hippocampus, 32(11-12), 808-817. https://doi.org/10.1002/hipo.23470

JYU-tekijät tai -toimittajat

Lehtonen, Suvi-Maaria
Waselius, Tomi
Penttonen, Markku
Nokia, Miriam

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Lehtonen, Suvi‐Maaria; Waselius, Tomi; Penttonen, Markku; Nokia, Miriam S.

Lehti tai sarja: Hippocampus

ISSN: 1050-9631

eISSN: 1098-1063

Julkaisuvuosi: 2022

Ilmestymispäivä: 16.09.2022

Volyymi: 32

Lehden numero: 11-12

Artikkelin sivunumerot: 808-817

Kustantaja: John Wiley & Sons

Julkaisumaa: Yhdysvallat (USA)

Julkaisun kieli: englanti

DOI: https://doi.org/10.1002/hipo.23470

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/83278

Tiivistelmä

Dentate gyrus (DG) is important for pattern separation and spatial memory, and it is thought to gate information flow to the downstream hippocampal subregions. Dentate spikes (DSs) are high-amplitude, fast, positive local-field potential events taking place in the DG during immobility and sleep, and they have been connected to memory consolidation in rodents. DSs are a result of signaling from the entorhinal cortex (EC) to the DG, and they suppress firing of pyramidal cells in the CA3 and CA1. To study the effects of DSs to signaling in the hippocampal tri-synaptic loop, we electrically stimulated the afferent fibers of the DG, CA3, and CA1 in adult male Sprague–Dawley rats at different delays from DSs. Responses to stimulation were increased in the EC-DG synapse during DSs, and the effect was amplified after theta-burst stimulation. We concluded that DSs strengthen the excitatory signal from the EC to the DG, which is reinforced by synapse potentiation and increased excitability of granule cells after theta-burst stimulation. This signal boosting may function in enhancing plastic changes in the DG-CA3 synapse. As responses in the CA3 and CA1 remained unaffected by the DS, the DS-contingent silencing of pyramidal cells seems to be a result of a decrease in excitatory input rather than a decrease in the excitability of the pyramidal cells themselves. In addition, we found that the DSs occur asynchronously in the left and right hippocampi, giving novel evidence of lateralization of the rodent hippocampus.

YSO-asiasanat: elektrofysiologia; hippokampus; muisti (kognitio); aivot; aivokuori

Vapaat asiasanat: dentate gyrus; electrophysiology; hippocampus; lateralization; synaptic transmission

Liittyvät organisaatiot

Hankkeet, joissa julkaisu on tehty

OKM-raportointi: Kyllä

VIRTA-lähetysvuosi: 2022

JUFO-taso: 1