A1 Journal article (refereed)
Depressive Symptoms and Mortality : Findings from Helsinki Birth Cohort Study (2023)
Eriksson, M. D., Eriksson, J. G., Korhonen, P., Koponen, H., Salonen, M. K., Mikkola, T. M., Kajantie, E., Wasenius, N. S., von Bonsdorff, M., Kautiainen, H., & Laine, M. K. (2023). Depressive Symptoms and Mortality : Findings from Helsinki Birth Cohort Study. Acta psychiatrica scandinavica, 147(2), 175-185. https://doi.org/10.1111/acps.13512
JYU authors or editors
Publication details
All authors or editors: Eriksson, Mia D.; Eriksson, Johan G.; Korhonen, Päivi; Koponen, Hannu; Salonen, Minna K.; Mikkola, Tuija M.; Kajantie, Eero; Wasenius, Niko S.; von Bonsdorff, Mikaela; Kautiainen, Hannu; et al.
Journal or series: Acta psychiatrica scandinavica
ISSN: 0001-690X
eISSN: 1600-0447
Publication year: 2023
Publication date: 20/10/2022
Volume: 147
Issue number: 2
Pages range: 175-185
Publisher: Wiley-Blackwell
Publication country: United States
Publication language: English
DOI: https://doi.org/10.1111/acps.13512
Publication open access: Openly available
Publication channel open access: Partially open access channel
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/83824
Abstract
Individuals with depression and depressive symptoms have a higher mortality rate than non-depressed individuals. The increased comorbidity and mortality associated with depression has remained largely unexplained. The underlying pathophysiological differences between depressive subtypes, melancholic and non-melancholic, may provide some explanation to this phenomenon.
Methods
1995 participants (mean age 61 years) from the Helsinki Birth Cohort Study were recruited for this prospective study and followed up for a mean of 14.1 years. Information regarding medical history, lifestyle, and biochemical parameters were obtained. Depressive symptoms were assessed using the Beck Depression Inventory. Standardized mortality ratios were calculated.
Results
Participants were followed up for a total of 28 044 person-years. The melancholic depressive group had an increased adjusted risk of mortality [HR 1.49 (95% CI: 1.02-2.20)] when compared to the non-depressive group. Comparing mortality to the whole population of Finland using standardized mortality ratios (SMR) both the non-melancholic [1.11 (95% CI: 0.85-1.44)] and melancholic depressive [1.26 (95% CI: 0.87-1.81)] groups had higher mortality than the non-depressive group [ 0.82 (95% CI: 0.73-0.93)].
Conclusions
Melancholic depressive symptoms are most strongly related to a higher mortality risk.
Keywords: mental health; mental disorders; mental health problems; depression (mental disorders); mortality; ageing; lifestyle; lifestyle habits; health; stress (biological phenomena)
Contributing organizations
Ministry reporting: Yes
Reporting Year: 2023
Preliminary JUFO rating: 2
