A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Depressive Symptoms and Mortality : Findings from Helsinki Birth Cohort Study (2023)


Eriksson, M. D., Eriksson, J. G., Korhonen, P., Koponen, H., Salonen, M. K., Mikkola, T. M., Kajantie, E., Wasenius, N. S., von Bonsdorff, M., Kautiainen, H., & Laine, M. K. (2023). Depressive Symptoms and Mortality : Findings from Helsinki Birth Cohort Study. Acta psychiatrica scandinavica, 147(2), 175-185. https://doi.org/10.1111/acps.13512


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajatEriksson, Mia D.; Eriksson, Johan G.; Korhonen, Päivi; Koponen, Hannu; Salonen, Minna K.; Mikkola, Tuija M.; Kajantie, Eero; Wasenius, Niko S.; von Bonsdorff, Mikaela; Kautiainen, Hannu; et al.

Lehti tai sarjaActa psychiatrica scandinavica

ISSN0001-690X

eISSN1600-0447

Julkaisuvuosi2023

Ilmestymispäivä20.10.2022

Volyymi147

Lehden numero2

Artikkelin sivunumerot175-185

KustantajaWiley-Blackwell

JulkaisumaaYhdysvallat (USA)

Julkaisun kielienglanti

DOIhttps://doi.org/10.1111/acps.13512

Julkaisun avoin saatavuusAvoimesti saatavilla

Julkaisukanavan avoin saatavuusOsittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX)https://jyx.jyu.fi/handle/123456789/83824


Tiivistelmä

Background
Individuals with depression and depressive symptoms have a higher mortality rate than non-depressed individuals. The increased comorbidity and mortality associated with depression has remained largely unexplained. The underlying pathophysiological differences between depressive subtypes, melancholic and non-melancholic, may provide some explanation to this phenomenon.

Methods
1995 participants (mean age 61 years) from the Helsinki Birth Cohort Study were recruited for this prospective study and followed up for a mean of 14.1 years. Information regarding medical history, lifestyle, and biochemical parameters were obtained. Depressive symptoms were assessed using the Beck Depression Inventory. Standardized mortality ratios were calculated.

Results
Participants were followed up for a total of 28 044 person-years. The melancholic depressive group had an increased adjusted risk of mortality [HR 1.49 (95% CI: 1.02-2.20)] when compared to the non-depressive group. Comparing mortality to the whole population of Finland using standardized mortality ratios (SMR) both the non-melancholic [1.11 (95% CI: 0.85-1.44)] and melancholic depressive [1.26 (95% CI: 0.87-1.81)] groups had higher mortality than the non-depressive group [ 0.82 (95% CI: 0.73-0.93)].

Conclusions
Melancholic depressive symptoms are most strongly related to a higher mortality risk.


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Liittyvät organisaatiot


OKM-raportointiKyllä

VIRTA-lähetysvuosi2023

JUFO-taso2


Viimeisin päivitys 2024-12-10 klo 15:31