A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Underweight and obesity are related to higher mortality in patients undergoing coronary angiography : The KARDIO invasive cardiology register study (2022)
Laukkanen, Jari A., Kunutsor, Setor K., Hernesniemi, Jussi, Immonen, Jaakko, Eskola, Markku, Zaccardi, Francesco, Niemelä, Matti, Mäkikallio, Timo, Hagnäs, Magnus, Piuhola, Jarkko, Juvonen, Jukka, Sia, Jussi, Rummukainen, Juha, Kervinen, Kari, Karvanen, Juha, Nikus, Kjell, KARDIO Study Group. (2022). Underweight and obesity are related to higher mortality in patients undergoing coronary angiography : The KARDIO invasive cardiology register study. Catheterization and Cardiovascular Interventions, 100(7), 1242-1251. https://doi.org/10.1002/ccd.30463
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Laukkanen, Jari A.; Kunutsor, Setor K.; Hernesniemi, Jussi; Immonen, Jaakko; Eskola, Markku; Zaccardi, Francesco; Niemelä, Matti; Mäkikallio, Timo; Hagnäs, Magnus; Piuhola, Jarkko; et al.
Lehti tai sarja: Catheterization and Cardiovascular Interventions
ISSN: 1522-1946
eISSN: 1522-726X
Julkaisuvuosi: 2022
Ilmestymispäivä: 15.11.2022
Volyymi: 100
Lehden numero: 7
Artikkelin sivunumerot: 1242-1251
Kustantaja: John Wiley & Sons
Julkaisumaa: Yhdysvallat (USA)
Julkaisun kieli: englanti
DOI: https://doi.org/10.1002/ccd.30463
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/83950
Tiivistelmä
In patients with some cardiovascular disease conditions, slightly elevated body mass index (BMI) is associated with a lower mortality risk (termed “obesity paradox”). It is uncertain, however, if this obesity paradox exists in patients who have had invasive cardiology procedures. We evaluated the association between BMI and mortality in patients who underwent coronary angiography.
Methods
We utilised the KARDIO registry, which comprised data on demographics, prevalent diseases, risk factors, coronary angiographies, and interventions on 42,636 patients. BMI was categorised based on WHO cut-offs or transformed using P-splines. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated for all-cause mortality.
Results
During a median follow-up of 4.9 years, 4688 all-cause deaths occurred. BMI was nonlinearly associated with mortality risk: compared to normal weight category (18.5–25 kg/m2), the age-adjusted HRs (95% CIs) for all-cause mortality were 1.90 (1.49, 2.43), 0.96 (0.92, 1.01), 1.04 (0.99, 1.09), 1.08 (0.96, 1.20), and 1.45 (1.22, 1.72) for underweight (<18.5 kg/m2), preobesity (25 to <30 kg/m2), obesity class I (30 to <35 kg/m2), obesity class II (35 to <40 kg/m2), and obesity class III (>40 kg/m2), respectively. The corresponding multivariable adjusted HRs (95% CIs) were 2.00 (1.55, 2.58), 0.92 (0.88, 0.97) 1.01 (0.95, 1.06), 1.10 (0.98, 1.23), and 1.49 (1.26, 1,78), respectively.
Conclusions
In patients undergoing coronary angiography, underweight and obesity class III are associated with increased mortality risk, and the lowest mortality was observed in the preobesity class. It appears the obesity paradox may be present in patients who undergo invasive coronary procedures.
YSO-asiasanat: sydän- ja verisuonitaudit; sepelvaltimotauti; varjoainetutkimus; kuolleisuus; painoindeksi; alipainoisuus; ylipaino; lihavuus; väestötutkimus; seurantatutkimus
Vapaat asiasanat: angiography; body mass index; coronary artery disease; hospital register; mortality
Liittyvät organisaatiot
OKM-raportointi: Kyllä
Raportointivuosi: 2022
JUFO-taso: 1
