A1 Journal article (refereed)
CD3+ and CD8+ T-Cell-Based Immune Cell Score and PD-(L)1 Expression in Pulmonary Metastases of Microsatellite Stable Colorectal Cancer (2023)
Karjula, T., Elomaa, H., Niskakangas, A., Mustonen, O., Puro, I., Kuopio, T., Ahtiainen, M., Mecklin, J.-P., Seppälä, T., Wirta, E.-V., Sihvo, E., Väyrynen, J., Yannopoulos, F., & Helminen, O. (2023). CD3+ and CD8+ T-Cell-Based Immune Cell Score and PD-(L)1 Expression in Pulmonary Metastases of Microsatellite Stable Colorectal Cancer. Cancers, 15(1), Article 206. https://doi.org/10.3390/cancers15010206
JYU authors or editors
Publication details
All authors or editors: Karjula, Topias; Elomaa, Hanna; Niskakangas, Anne; Mustonen, Olli; Puro, Iiris; Kuopio, Teijo; Ahtiainen, Maarit; Mecklin, Jukka-Pekka; Seppälä, Toni, T.; Wirta, Erkki-Ville; et al.
Journal or series: Cancers
eISSN: 2072-6694
Publication year: 2023
Publication date: 29/12/2022
Volume: 15
Issue number: 1
Article number: 206
Publisher: MDPI AG
Publication country: Switzerland
Publication language: English
DOI: https://doi.org/10.3390/cancers15010206
Publication open access: Openly available
Publication channel open access: Open Access channel
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/85263
Abstract
The lung is the second most common site of metastases in colorectal cancer (CRC). The aim of our study was to evaluate the prognostic value of CD3+ and CD8+ T-cell density based immune cell score (ICS) and PD-1/PD-L1 expression in resected pulmonary metastases of microsatellite stable CRC. The T-cell infiltration was higher in the first pulmonary metastases compared to primary tumour. Pulmonary metastases with high ICS had improved survival compared to low ICS after adjusting for confounders. High tumour cell PD-L1 expression was associated with favourable prognosis. Our results might have clinical feasibility in planning future therapies.
Abstract
The objective of this study was to evaluate the prognostic value of CD3+ and CD8+ based immune cell score (ICS), programmed death -1 (PD-1) and programmed death ligand -1 (PD-L1) in pulmonary metastases of proficient mismatch repair colorectal cancer (CRC) patients. A total of 101 pulmonary metastases and 62 primary CRC tumours were stained for CD3+, CD8+, PD-1 and PD-L1 expression. The prognostic value of ICS, PD-1/PD-L1 expression in 67 first pulmonary metastases and 61 primary CRC tumour was analysed. Comparative analysis was also performed between primary tumours and pulmonary metastases, as well as between T-cell densities and PD-1/PD-L1 expression. The 5-year overall survival rates of low, intermediate, and high ICS in pulmonary metastases were 10.0%, 25.5% and 47.0% (p = 0.046), respectively. Patients with high vs. low ICS in pulmonary metastases had a significantly better 5-year survival (adjusted HR 0.25, 95% CI 0.09–0.75, p = 0.013). High tumour cell PD-L1 expression in the pulmonary metastases was associated with improved survival (p = 0.024). Primary tumour CD8+ expression was significantly correlated with all T-cell densities in pulmonary metastases. Conclusion: The ICS evaluated from the resected pulmonary metastases of CRC showed significant prognostic value. High PD-L1 expression in pulmonary metastases is associated with favourable prognosis.
Keywords: cancerous diseases; carcinomas; cancer of the large intestine; metastases; lungs
Free keywords: colorectal carcinoma; pulmonary metastases; tumour-infiltrating lymphocytes; programmed death 1; programmed death ligand 1
Contributing organizations
Ministry reporting: Yes
VIRTA submission year: 2023
JUFO rating: 1
