A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Cross‐sectional associations between physical fitness and biomarkers of inflammation in children : the PANIC study (2023)
Haapala, E. A., Kuronen, E., Ihalainen, J. K., Lintu, N., Leppänen, M. H., Tompuri, T., Atalay, M., Schwab, U., & Lakka, T. A. (2023). Cross‐sectional associations between physical fitness and biomarkers of inflammation in children : the PANIC study. Scandinavian Journal of Medicine and Science in Sports, 33(6), 1000-1009. https://doi.org/10.1111/sms.14337
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Haapala, Eero A.; Kuronen, Emmi; Ihalainen, Johanna K.; Lintu, Niina; Leppänen, Marja H.; Tompuri, Tuomo; Atalay, Mustafa; Schwab, Ursula; Lakka, Timo A.
Lehti tai sarja: Scandinavian Journal of Medicine and Science in Sports
ISSN: 0905-7188
eISSN: 1600-0838
Julkaisuvuosi: 2023
Ilmestymispäivä: 13.02.2023
Volyymi: 33
Lehden numero: 6
Artikkelin sivunumerot: 1000-1009
Kustantaja: Wiley
Julkaisumaa: Britannia
Julkaisun kieli: englanti
DOI: https://doi.org/10.1111/sms.14337
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/87112
Tiivistelmä
Systemic low-grade inflammation has been proposed as an underlying pathophysiological mechanism for cardiometabolic diseases. We investigated the associations of physical fitness with systemic low-grade inflammatory state in a population sample of children.
Methods
Altogether 391 children aged 6–9 years were examined. Cardiorespiratory fitness (maximal power output, Wmax) was assessed by a maximal cycle ergometer test and neuromuscular fitness by hand grip strength, sit-up, standing long jump, 50-metre shuttle run, static balance, sit-and-reach, and box and block tests. Body fat percentage (BF%) and lean mass (LM) were assessed by dual-energy X-ray absorptiometry. High sensitivity C-reactive protein (hs-CRP), leptin, leptin receptor, high molecular weight adiponectin (HMW-adiponectin), interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-α), and glycoprotein acetyls (GlycA) were assessed from fasting blood samples. The modified inflammatory score (IS) was calculated using the population specific z-scores and formula (zhs-CRP + zleptin + zIL-6 + zTNF-α + zGlycA) – zleptin receptor – zHMW-adiponectin. The data were analysed using linear regression analyses.
Results
Higher Wmax/kg of body mass (β=-0.416, 95% CI=-0.514 to -0.318), higher number of completed sit-ups (β=-0.147, 95% CI=-0.244 to -0.049), a longer distance jumped in the standing long jump test (β=-0.270, 95% CI=-0.371 to -0.169), and a shorter time in the 50 metre shuttle run test (β=0.123, 95% CI=0.022 to 0.223) were associated with lower IS. None of these associations remained statistically significant after adjustment for BF%
Conclusions
Higher physical fitness is associated with more favourable inflammatory biomarker profile in children. However, the associations were explained by BF%.
YSO-asiasanat: matala-asteinen tulehdus; biomarkkerit; fyysinen kunto; kehonkoostumus; lihavuus; lapset (ikäryhmät)
Vapaat asiasanat: inflammation; biomarkers; physical fitness; fitness; paediatrics; obesity; low-grade inflammation
Liittyvät organisaatiot
OKM-raportointi: Kyllä
Raportointivuosi: 2023
Alustava JUFO-taso: 2
