A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Development and validation of an intrinsic capacity composite score in the Longitudinal Aging Study Amsterdam : a formative approach (2023)

Koivunen, K., Hoogendijk, E. O., Schaap, L. A., Huisman, M., Heymans, M. W., & van Schoor, N. M. (2023). Development and validation of an intrinsic capacity composite score in the Longitudinal Aging Study Amsterdam : a formative approach. Aging Clinical and Experimental Research, 35(4), 815-825. https://doi.org/10.1007/s40520-023-02366-2

JYU-tekijät tai -toimittajat

Koivunen, Kaisa

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Koivunen, Kaisa; Hoogendijk, Emiel O.; Schaap, Laura A.; Huisman, Martijn; Heymans, Martijn W.; van Schoor, Natasja M.

Lehti tai sarja: Aging Clinical and Experimental Research

ISSN: 1594-0667

eISSN: 1720-8319

Julkaisuvuosi: 2023

Ilmestymispäivä: 23.02.2023

Volyymi: 35

Lehden numero: 4

Artikkelin sivunumerot: 815-825

Kustantaja: Springer Science and Business Media LLC

Julkaisumaa: Italia

Julkaisun kieli: englanti

DOI: https://doi.org/10.1007/s40520-023-02366-2

Linkki tutkimusaineistoon: https://www.lasa-vu.nl/

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/85719

Lisätietoja: The datasets generated during the current study are not publicly available due to confidentiality, but the data underlying the results presented in this study are available from the Longitudinal Aging Study Amsterdam (LASA) and may be requested for research purposes. More information on data requests can be found on the LASA website: www.lasa-vu.nl.

Tiivistelmä

Background
Intrinsic capacity (IC) defined by the WHO refers to the composite of five domains of capacities. So far, developing and validating a standardized overall score of the concept have been challenging partly because its conceptual framework has been unclear. We consider that a person’s IC is determined by its domain-specific indicators suggesting a formative measurement model.

Aims
To develop an IC score applying a formative approach and assess its validity.

Methods
The study sample (n = 1908) consisted of 57–88-year-old participants from the Longitudinal Aging Study Amsterdam (LASA). We used logistic regression models to select the indicators to the IC score with 6-year functional decline as an outcome. An IC score (range 0–100) was constructed for each participant. We examined the known-groups’ validity of the IC score by comparing groups based on age and number of chronic diseases. The criterion validity of the IC score was assessed with 6-year functional decline and 10-year mortality as outcomes.

Results
The constructed IC score included seven indicators covering all five domains of the construct. The mean IC score was 66.7 (SD 10.3). The scores were higher among younger participants and those who had lower number of chronic diseases. After adjustment for sociodemographic indicators, chronic diseases, and BMI, a one-point higher IC score was associated with a 7% decreased risk for 6-year functional decline and a 2% decreased risk for 10-year mortality.

Conclusions
The developed IC score demonstrated discriminative ability according to age and health status and is associated with subsequent functional decline and mortality.

YSO-asiasanat: ikääntyneet; ikääntyminen; toimintakyky; mittarit (mittaus); validiteetti

Vapaat asiasanat: functional ability; healthy aging; measurement; WHO

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