A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Inflammatory proteomics profiling for prediction of incident atrial fibrillation (2023)


Börschel, C. S., Ortega-Alonso, A., Havulinna, A. S., Jousilahti, P., Salmi, M., Jalkanen, S., Salomaa, V., Niiranen, T., & Schnabel, R. B. (2023). Inflammatory proteomics profiling for prediction of incident atrial fibrillation. Heart, 109(13), 1000-1006. https://doi.org/10.1136/heartjnl-2022-321959


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Börschel, Christin S.; Ortega-Alonso, Alfredo; Havulinna, Aki S.; Jousilahti, Pekka; Salmi, Marko; Jalkanen, Sirpa; Salomaa, Veikko; Niiranen, Teemu; Schnabel, Renate B.

Lehti tai sarja: Heart

ISSN: 1355-6037

eISSN: 1468-201X

Julkaisuvuosi: 2023

Ilmestymispäivä: 17.02.2023

Volyymi: 109

Lehden numero: 13

Artikkelin sivunumerot: 1000-1006

Kustantaja: BMJ Publishing Group

Julkaisumaa: Britannia

Julkaisun kieli: englanti

DOI: https://doi.org/10.1136/heartjnl-2022-321959

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/85947


Tiivistelmä

Objective Atrial fibrillation (AF) has emerged as a common condition in older adults. Cardiovascular risk factors only explain about 50% of AF cases. Inflammatory biomarkers may help close this gap as inflammation can alter atrial electrophysiology and structure. This study aimed to determine a cytokine biomarker profile for this condition in the community using a proteomics approach.

Methods This study uses cytokine proteomics in participants of the Finnish population-based FINRISK cohort studies 1997/2002. Risk models for 46 cytokines were developed to predict incident AF using Cox regressions. Furthermore, the association of participants’ C reactive protein (CRP) and N-terminal pro B-type natriuretic peptide (NT-proBNP) concentrations with incident AF was examined.

Results In 10 744 participants (mean age of 50.9 years, 51.3% women), 1246 cases of incident AF were observed (40.5% women). The main analyses, adjusted for participants’ sex and age, suggested that higher concentrations of macrophage inflammatory protein-1β (HR=1.11; 95% CI 1.04, 1.17), hepatocyte growth factor (HR=1.12; 95% CI 1.05, 1.19), CRP (HR=1.17; 95% CI 1.10, 1.24) and NT-proBNP (HR=1.58; 95% CI 1.45, 1.71) were associated with increased risk of incident AF. In further clinical variable-adjusted models, only NT-proBNP remained statistically significant.

Conclusion Our study confirmed NT-proBNP as a strong predictor for AF. Observed associations of circulating inflammatory cytokines were primarily explained by clinical risk factors and did not improve risk prediction. The potential mechanistic role of inflammatory cytokines measured in a proteomics approach remains to be further elucidated.


YSO-asiasanat: sydän- ja verisuonitaudit; eteisvärinä; ennusteet; matala-asteinen tulehdus; biomarkkerit; proteomiikka; sytokiinit; c-reaktiivinen proteiini


Liittyvät organisaatiot


OKM-raportointi: Kyllä

VIRTA-lähetysvuosi: 2023

JUFO-taso: 2


Viimeisin päivitys 2024-12-10 klo 17:00