A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Probing the Gelation Synergies and Anti-Escherichia coli Activity of Fmoc-Phenylalanine/Graphene Oxide Hybrid Hydrogel (2023)


Sitsanidis, E. D., A. L. Dutra, L., Schirmer, J., Chevigny, R., Lahtinen, M., Johansson, A., Piras, C. C., Smith, D. K., Tiirola, M., Pettersson, M., & Nissinen, M. (2023). Probing the Gelation Synergies and Anti-Escherichia coli Activity of Fmoc-Phenylalanine/Graphene Oxide Hybrid Hydrogel. ACS Omega, 8(11), 10225-10234. https://doi.org/10.1021/acsomega.2c07700


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Sitsanidis, Efstratios D.; A. L. Dutra, Lara; Schirmer, Johanna; Chevigny, Romain; Lahtinen, Manu; Johansson, Andreas; Piras, Carmen C.; Smith, David K.; Tiirola, Marja; Pettersson, Mika; et al.

Lehti tai sarja: ACS Omega

eISSN: 2470-1343

Julkaisuvuosi: 2023

Ilmestymispäivä: 08.03.2023

Volyymi: 8

Lehden numero: 11

Artikkelin sivunumerot: 10225-10234

Kustantaja: American Chemical Society (ACS)

Julkaisumaa: Yhdysvallat (USA)

Julkaisun kieli: englanti

DOI: https://doi.org/10.1021/acsomega.2c07700

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/86111


Tiivistelmä

The N-fluorenyl-9-methyloxycarbonyl (Fmoc)-protected amino acids have shown high antimicrobial application potential, among which the phenylalanine derivative (Fmoc-F) is the most well-known representative. However, the activity spectrum of Fmoc-F is restricted to Gram-positive bacteria only. The demand for efficient antimicrobial materials expanded research into graphene and its derivatives, although the reported results are somewhat controversial. Herein, we combined graphene oxide (GO) flakes with Fmoc-F amino acid to form Fmoc-F/GO hybrid hydrogel for the first time. We studied the synergistic effect of each component on gelation and assessed the material’s bactericidal activity on Gram-negative Escherichia coli (E. coli). GO flakes do not affect Fmoc-F self-assembly per se but modulate the elasticity of the gel and speed up its formation. The hybrid hydrogel affects E. coli survival, initially causing abrupt bacterial death followed by the recovery of the surviving ones due to the inoculum effect (IE). The combination of graphene with amino acids is a step forward in developing antimicrobial gels due to their easy preparation, chemical modification, graphene functionalization, cost-effectiveness, and physicochemical/biological synergy of each component.


YSO-asiasanat: bakteerit; hydrogeelit; peptidit; proteiinit; hyytyminen

Vapaat asiasanat: bacteria; gelation; hydrogels; monomers; peptides; proteins


Liittyvät organisaatiot


OKM-raportointi: Kyllä

VIRTA-lähetysvuosi: 2023

JUFO-taso: 1


Viimeisin päivitys 2025-06-03 klo 00:45