A1 Journal article (refereed)
Immunological and prognostic significance of tumour necrosis in colorectal cancer (2023)
Kastinen, M., Sirniö, P., Elomaa, H., Ahtiainen, M., Väyrynen, S. A., Herzig, K.-H., Meriläinen, S., Aro, R., Häivälä, R., Rautio, T., Saarnio, J., Wirta, E.-V., Helminen, O., Seppälä, T. T., Kuopio, T., Böhm, J., Tuomisto, A., Mecklin, J.-P., Mäkinen, M. J., & Väyrynen, J. P. (2023). Immunological and prognostic significance of tumour necrosis in colorectal cancer. British Journal of Cancer, 128(12), 2218-2226. https://doi.org/10.1038/s41416-023-02258-2
JYU authors or editors
Publication details
All authors or editors: Kastinen, Meeri; Sirniö, Päivi; Elomaa, Hanna; Ahtiainen, Maarit; Väyrynen, Sara A.; Herzig, Karl-Heinz; Meriläinen, Sanna; Aro, Raila; Häivälä, Reetta; Rautio, Tero; et al.
Journal or series: British Journal of Cancer
ISSN: 0007-0920
eISSN: 1532-1827
Publication year: 2023
Publication date: 08/04/2023
Volume: 128
Issue number: 12
Pages range: 2218-2226
Publisher: Nature Publishing Group
Publication country: United Kingdom
Publication language: English
DOI: https://doi.org/10.1038/s41416-023-02258-2
Publication open access: Openly available
Publication channel open access: Partially open access channel
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/86353
Abstract
Colorectal cancer (CRC) causes the second most cancer deaths worldwide, but the disease course varies according to tumour characteristics and immunological factors. Our objective was to examine the associations of tumour necrosis with tumour characteristics, immune cell infiltrates, serum cytokine concentrations, as well as prognosis in CRC.
Methods
Three independent CRC cohorts, including 1413 patients, were analysed. Associations of the areal percentage of tumour necrosis with clinicopathologic parameters, tumour infiltrating immune cells, cytokine concentrations in systemic and mesenteric vein blood, and survival were examined.
Results
Higher tumour necrosis percentage associated with shorter colorectal cancer-specific survival independent of tumour grade, T, N or M-class, mismatch repair status, BRAF status, and other possible confounding factors. In the largest cohort (N = 1100), the HR for high tumour necrosis percentage (≥40% vs. <3%) was 3.22 (95% CI 1.68–6.17, Ptrend < 0.0001). Tumour necrosis percentage positively correlated with peripheral serum levels of CXCL8, a proinflammatory chemokine, and negatively correlated with mesenteric serum levels of CXCL10 and mast cell densities in the invasive margin of the tumour.
Conclusions
Our results support the value of tumour necrosis as a prognostic factor in colorectal cancer. CXCL8 may have a role in the systemic effects of tumour necrosis.
Keywords: cancerous diseases; tumours; biomarkers
Free keywords: cancer microenvironment; colorectal cancer; tumour biomarkers
Contributing organizations
Ministry reporting: Yes
VIRTA submission year: 2023
JUFO rating: 2
