A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Immunological and prognostic significance of tumour necrosis in colorectal cancer (2023)


Kastinen, M., Sirniö, P., Elomaa, H., Ahtiainen, M., Väyrynen, S. A., Herzig, K.-H., Meriläinen, S., Aro, R., Häivälä, R., Rautio, T., Saarnio, J., Wirta, E.-V., Helminen, O., Seppälä, T. T., Kuopio, T., Böhm, J., Tuomisto, A., Mecklin, J.-P., Mäkinen, M. J., & Väyrynen, J. P. (2023). Immunological and prognostic significance of tumour necrosis in colorectal cancer. British Journal of Cancer, 128(12), 2218-2226. https://doi.org/10.1038/s41416-023-02258-2


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajatKastinen, Meeri; Sirniö, Päivi; Elomaa, Hanna; Ahtiainen, Maarit; Väyrynen, Sara A.; Herzig, Karl-Heinz; Meriläinen, Sanna; Aro, Raila; Häivälä, Reetta; Rautio, Tero; et al.

Lehti tai sarjaBritish Journal of Cancer

ISSN0007-0920

eISSN1532-1827

Julkaisuvuosi2023

Ilmestymispäivä08.04.2023

Volyymi128

Lehden numero12

Artikkelin sivunumerot2218-2226

KustantajaNature Publishing Group

JulkaisumaaBritannia

Julkaisun kielienglanti

DOIhttps://doi.org/10.1038/s41416-023-02258-2

Julkaisun avoin saatavuusAvoimesti saatavilla

Julkaisukanavan avoin saatavuusOsittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX)https://jyx.jyu.fi/handle/123456789/86353


Tiivistelmä

Background
Colorectal cancer (CRC) causes the second most cancer deaths worldwide, but the disease course varies according to tumour characteristics and immunological factors. Our objective was to examine the associations of tumour necrosis with tumour characteristics, immune cell infiltrates, serum cytokine concentrations, as well as prognosis in CRC.

Methods
Three independent CRC cohorts, including 1413 patients, were analysed. Associations of the areal percentage of tumour necrosis with clinicopathologic parameters, tumour infiltrating immune cells, cytokine concentrations in systemic and mesenteric vein blood, and survival were examined.

Results
Higher tumour necrosis percentage associated with shorter colorectal cancer-specific survival independent of tumour grade, T, N or M-class, mismatch repair status, BRAF status, and other possible confounding factors. In the largest cohort (N = 1100), the HR for high tumour necrosis percentage (≥40% vs. <3%) was 3.22 (95% CI 1.68–6.17, Ptrend < 0.0001). Tumour necrosis percentage positively correlated with peripheral serum levels of CXCL8, a proinflammatory chemokine, and negatively correlated with mesenteric serum levels of CXCL10 and mast cell densities in the invasive margin of the tumour.

Conclusions
Our results support the value of tumour necrosis as a prognostic factor in colorectal cancer. CXCL8 may have a role in the systemic effects of tumour necrosis.


YSO-asiasanatsyöpätauditkasvaimetbiomarkkerit

Vapaat asiasanatcancer microenvironment; colorectal cancer; tumour biomarkers


Liittyvät organisaatiot


OKM-raportointiKyllä

VIRTA-lähetysvuosi2023

JUFO-taso2


Viimeisin päivitys 2024-12-10 klo 16:30