A1 Journal article (refereed)
Gut microbiome and atrial fibrillation : results from a large population-based study (2023)
Palmu, J., Börschel, C. S., Ortega-Alonso, A., Markó, L., Inouye, M., Jousilahti, P., Salido, R. A., Sanders, K., Brennan, C., Humphrey, G. C., Sanders, J. G., Gutmann, F., Linz, D., Salomaa, V., Havulinna, A. S., Forslund, S. K., Knight, R., Lahti, L., Niiranen, T., & Schnabel, R. B. (2023). Gut microbiome and atrial fibrillation : results from a large population-based study. EBioMedicine, 91, Article 104583. https://doi.org/10.1016/j.ebiom.2023.104583
JYU authors or editors
Publication details
All authors or editors: Palmu, Joonatan; Börschel, Christin S.; Ortega-Alonso, Alfredo; Markó, Lajos; Inouye, Michael; Jousilahti, Pekka; Salido, Rodolfo A.; Sanders, Karenina; Brennan, Caitriona; Humphrey, Gregory C.; et al.
Journal or series: EBioMedicine
eISSN: 2352-3964
Publication year: 2023
Publication date: 27/04/2023
Volume: 91
Article number: 104583
Publisher: Elsevier BV
Publication country: Netherlands
Publication language: English
DOI: https://doi.org/10.1016/j.ebiom.2023.104583
Publication open access: Openly available
Publication channel open access: Open Access channel
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/86756
Abstract
Atrial fibrillation (AF) is an important heart rhythm disorder in aging populations. The gut microbiome composition has been previously related to cardiovascular disease risk factors. Whether the gut microbial profile is also associated with the risk of AF remains unknown.
Methods
We examined the associations of prevalent and incident AF with gut microbiota in the FINRISK 2002 study, a random population sample of 6763 individuals. We replicated our findings in an independent case–control cohort of 138 individuals in Hamburg, Germany.
Findings
Multivariable-adjusted regression models revealed that prevalent AF (N = 116) was associated with nine microbial genera. Incident AF (N = 539) over a median follow-up of 15 years was associated with eight microbial genera with false discovery rate (FDR)-corrected P < 0.05. Both prevalent and incident AF were associated with the genera Enorma and Bifidobacterium (FDR-corrected P < 0.001). AF was not significantly associated with bacterial diversity measures. Seventy-five percent of top genera (Enorma, Paraprevotella, Odoribacter, Collinsella, Barnesiella, Alistipes) in Cox regression analyses showed a consistent direction of shifted abundance in an independent AF case–control cohort that was used for replication.
Interpretation
Our findings establish the basis for the use of microbiome profiles in AF risk prediction. However, extensive research is still warranted before microbiome sequencing can be used for prevention and targeted treatment of AF.
Funding
This study was funded by European Research Council, German Ministry of Research and Education, Academy of Finland, Finnish Medical Foundation, and the Finnish Foundation for Cardiovascular Research, the Emil Aaltonen Foundation, and the Paavo Nurmi Foundation.
Keywords: cardiovascular diseases; arrhythmias; atrial fibrillation; risk factors; gastrointestinal microbiota; epidemiology
Free keywords: atrial fibrillation; gut microbiome; metagenomics; epidemiology
Contributing organizations
Ministry reporting: Yes
Reporting Year: 2023
Preliminary JUFO rating: 1
