A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
CA3–CA1 long‐term potentiation occurs regardless of respiration and cardiac cycle phases in urethane‐anesthetized rats (2023)
Nokia, M. S., Waselius, T., & Penttonen, M. (2023). CA3–CA1 long‐term potentiation occurs regardless of respiration and cardiac cycle phases in urethane‐anesthetized rats. Hippocampus, 33(11), 1228-1232. https://doi.org/10.1002/hipo.23551
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Nokia, Miriam S.; Waselius, Tomi; Penttonen, Markku
Lehti tai sarja: Hippocampus
ISSN: 1050-9631
eISSN: 1098-1063
Julkaisuvuosi: 2023
Ilmestymispäivä: 23.05.2023
Volyymi: 33
Lehden numero: 11
Artikkelin sivunumerot: 1228-1232
Kustantaja: Wiley
Julkaisumaa: Yhdysvallat (USA)
Julkaisun kieli: englanti
DOI: https://doi.org/10.1002/hipo.23551
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/87468
Tiivistelmä
Breathing and heartbeat synchronize to each other and to brain function and affect cognition in humans. However, it is not clear how cardiorespiratory rhythms modulate such basic processes as synaptic plasticity thought to underlie learning. Thus, we studied if respiration and cardiac cycle phases at burst stimulation onset affect hippocampal long-term potentiation (LTP) in the CA3–CA1 synapse in urethane-anesthetized adult male Sprague–Dawley rats. In a between-subjects design, we timed burst stimulation of the ventral hippocampal commissure (vHC) to systole or diastole either during expiration or inspiration and recorded responses throughout the hippocampus with a linear probe. As classical conditioning in humans seems to be most efficient at expiration-diastole, we also expected LTP to be most efficient if burst stimulation was targeted to expiration-diastole. However, LTP was induced equally in all four groups and respiration and cardiac cycle phase did not modulate CA1 responses to vHC stimulation overall. This could be perhaps because we bypassed all natural routes of external influences on the CA1 by directly stimulating the vHC. In the future, the effect of cardiorespiratory rhythms on synaptic plasticity could also be studied in awake state and in other parts of the hippocampal tri-synaptic loop.
YSO-asiasanat: hippokampus; aivot; sydän; syke; hengitys; oppiminen; muisti (kognitio); neuroplastisuus
Vapaat asiasanat: breathing; heartbeat; hippocampus; learning; memory; plasticity
Liittyvät organisaatiot
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OKM-raportointi: Kyllä
Raportointivuosi: 2023
Alustava JUFO-taso: 1