A1 Journal article (refereed)
Age but not menopausal status is linked to lower resting energy expenditure (2023)

Karppinen, J. E., Wiklund, P., Ihalainen, J. K., Juppi, H.-K., Isola, V., Hyvärinen, M., Ahokas, E. K., Kujala, U. M., Laukkanen, J., Hulmi, J. J., Ahtiainen, J. P., Cheng, S., & Laakkonen, E. K. (2023). Age but not menopausal status is linked to lower resting energy expenditure. Journal of Clinical Endocrinology and Metabolism, 108(11), 2789-2797. https://doi.org/10.1210/clinem/dgad321

JYU authors or editors

Karppinen, Jari
Ihalainen, Johanna
Juppi, Hanna-Kaarina
Isola, Ville
Hyvärinen, Matti
Ahokas, Essi
Kujala, Urho
Hulmi, Juha
Ahtiainen, Juha
Cheng, Shulin
Laakkonen, Eija

Publication details

All authors or editors: Karppinen, Jari E.; Wiklund, Petri; Ihalainen, Johanna K.; Juppi, Hanna-Kaarina; Isola, Ville; Hyvärinen, Matti; Ahokas, Essi K.; Kujala, Urho M.; Laukkanen, Jari; Hulmi, Juha J.; et al.

Journal or series: Journal of Clinical Endocrinology and Metabolism

ISSN: 0021-972X

eISSN: 1945-7197

Publication year: 2023

Publication date: 02/06/2023

Volume: 108

Issue number: 11

Pages range: 2789-2797

Publisher: Oxford University Press; The Endocrine Society

Publication country: United States

Publication language: English

DOI: https://doi.org/10.1210/clinem/dgad321

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/90875

Web address of parallel published publication (pre-print): https://www.biorxiv.org/content/10.1101/2022.12.16.520683v1

Abstract

Context
It remains uncertain whether aging before late adulthood and menopause are associated with fat-free mass and fat mass–adjusted resting energy expenditure (REEadj).

Objectives
We investigated whether REEadj differs between middle-aged and younger women and between middle-aged women with different menopausal statuses. We repeated the age group comparison between middle-aged mothers and their daughters to partially control for genotype. We also explored whether serum estradiol and follicle-stimulating hormone concentrations explain REEadj in midlife.

Methods
We divided 120 women, including 16 mother–daughter pairs, into age groups; group I (n=26) consisted of participants aged 17–21, group II (n=35) of those aged 22–38 and group III (n=59) of those aged 41–58 years. The women in group III were further categorized as pre- or perimenopausal (n=19), postmenopausal (n=30) or postmenopausal hormone therapy users (n=10). REE was assessed using indirect calorimetry, body composition using dual-energy X-ray absorptiometry and hormones using immunoassays.

Results
The REEadj of group I was 126 kcal/d (95% CI: 93–160) higher than that of group III, and the REEadj of group II was 88 kcal/d (95% CI: 49–127) higher. Furthermore, daughters had a 100 kcal/d (95% CI: 63–138 kcal/d) higher REEadj than their middle-aged mothers (all P<0.001). In group III, REEadj was not lower in postmenopausal women and did not vary by sex hormone concentrations.

Conclusions
We demonstrated that REEadj declines with age in women before late adulthood, also when controlling partially for genetic background, and that menopause may not contribute to this decline.

Keywords: energy consumption (metabolism); hormonal factors; estrogens; menopause; hormone therapy; ageing; women