A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Tertiary lymphoid structures in pulmonary metastases of microsatellite stable colorectal cancer (2023)
Karjula, T., Niskakangas, A., Mustonen, O., Puro, I., Elomaa, H., Ahtiainen, M., Kuopio, T., Mecklin, J.-P., Seppälä, T. T., Wirta, E.-V., Sihvo, E., Yannopoulos, F., Helminen, O., & Väyrynen, J. P. (2023). Tertiary lymphoid structures in pulmonary metastases of microsatellite stable colorectal cancer. Virchows Archiv, 483, 21-32. https://doi.org/10.1007/s00428-023-03577-8
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Karjula, Topias; Niskakangas, Anne; Mustonen, Olli; Puro, Iiris; Elomaa, Hanna; Ahtiainen, Maarit; Kuopio, Teijo; Mecklin, Jukka-Pekka; Seppälä, Toni T.; Wirta, Erkki-Ville; et al.
Lehti tai sarja: Virchows Archiv
ISSN: 0945-6317
eISSN: 1432-2307
Julkaisuvuosi: 2023
Ilmestymispäivä: 20.06.2023
Volyymi: 483
Artikkelin sivunumerot: 21-32
Kustantaja: Springer
Julkaisumaa: Saksa
Julkaisun kieli: englanti
DOI: https://doi.org/10.1007/s00428-023-03577-8
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/88004
Tiivistelmä
Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates located at sites of chronic inflammation and recognized as prognosticators in several cancers. We aimed to analyse the prognostic effect of TLSs in colorectal cancer (CRC) pulmonary metastases and primary tumours, with a comparison to the CD3+ and CD8+ cell density-based immune cell score (ICS). For TLS density and TLS maximum diameter analysis, 67 pulmonary metastases and 63 primary tumours were stained with haematoxylin and eosin. For ICS scoring and analysis, CD3 and CD8 immunohistochemistry was performed. Excellent interobserver agreement was achieved in all TLS measurements. Of all patients, 36 patients had low TLS density (< 0.222 follicles/mm) and 31 patients had high TLS density (≥ 0.222 follicles/mm) in the first resected pulmonary metastases. TLS density (adjusted HR 0.91, 0.48–1.73) or maximum diameter (adjusted HR 0.78, 0.40–1.51) did not have prognostic value in pulmonary metastases. In primary tumours, higher TLS density (adjusted HR 0.39, 0.18–0.87) and maximum diameter (adjusted HR 0.28, 0.11–0.73) were associated with lower mortality. In the pulmonary metastases, ICS had superior prognostic value to TLSs; however, TLSs and ICS were significantly associated. In conclusion, TLSs in CRC pulmonary metastases had no prognostic value but correlated with the ICS. TLSs in primary tumours associated with favourable prognosis.
YSO-asiasanat: syöpätaudit; paksusuolisyöpä; etäpesäkkeet; keuhkot; kasvaimet; ennusteet
Vapaat asiasanat: tertiary lymphoid structures; pulmonary metastasis; microsatellite stable colorectal cancer
Liittyvät organisaatiot
OKM-raportointi: Kyllä
VIRTA-lähetysvuosi: 2023
JUFO-taso: 1
