A1 Journal article (refereed)
Mechanochemical Difluoromethylations of Alcohols (2023)

van Bonn, P., Ke, J., Weike, C., Ward, J. S., Rissanen, K., & Bolm, C. (2023). Mechanochemical Difluoromethylations of Alcohols. CCS chemistry, 5(8), 1737-1744. https://doi.org/10.31635/ccschem.023.202302783

JYU authors or editors

Publication details

All authors or editors: van Bonn, Pit; Ke, Jinbo; Weike, Christopher; Ward, Jas S.; Rissanen, Kari; Bolm, Carsten

Journal or series: CCS chemistry

ISSN: 2096-5745

Publication year: 2023

Publication date: 02/06/2023

Volume: 5

Issue number: 8

Pages range: 1737-1744

Publisher: Chinese Chemical Society

Publication country: China

Publication language: English

DOI: https://doi.org/10.31635/ccschem.023.202302783

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/88648

Abstract

Difluoromethyl ethers are formed through mechanochemical reactions of alcohols with difluorocarbene in a mixer mill. The protocol could be applied to primary, secondary, and tertiary alcohols, yielding the corresponding products in excellent yields (up to 99%) after 1 h reaction time at room temperature. The transformations proceeded under solvent-free reaction conditions, followed by product purification by filtration, which drastically reduced the amount of waste generated during the process.

Keywords: chemical reactions; alcohols (organic compounds)

Free keywords: mechanochemistry; ball milling; solvent-free reaction; difluorocarbene; difluoromethyl ether

Contributing organizations

Ministry reporting: Yes

VIRTA submission year: 2023

JUFO rating: 1