A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Altered corpus callosum structure in adolescents with cerebral palsy : connection to gait and balance (2023)

Jaatela, J., Nurmi, T., Vallinoja, J., Mäenpää, H., Sairanen, V., & Piitulainen, H. (2023). Altered corpus callosum structure in adolescents with cerebral palsy : connection to gait and balance. Brain Structure and Function, 228, 1901-1915. https://doi.org/10.1007/s00429-023-02692-1

JYU-tekijät tai -toimittajat

Nurmi, Timo
Piitulainen, Harri

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Jaatela, Julia; Nurmi, Timo; Vallinoja, Jaakko; Mäenpää, Helena; Sairanen, Viljami; Piitulainen, Harri

Lehti tai sarja: Brain Structure and Function

ISSN: 1863-2653

eISSN: 1863-2661

Julkaisuvuosi: 2023

Ilmestymispäivä: 24.08.2023

Volyymi: 228

Artikkelin sivunumerot: 1901-1915

Kustantaja: Springer Science and Business Media LLC

Julkaisumaa: Saksa

Julkaisun kieli: englanti

DOI: https://doi.org/10.1007/s00429-023-02692-1

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/88893

Tiivistelmä

Cerebral palsy (CP) is the most common motor disorder in childhood. Recent studies in children with CP have associated weakened sensorimotor performance with impairments in the major brain white-matter (WM) structure, corpus callosum (CC). However, the relationship between CC structure and lower extremity performance, specifcally gait and balance, remains unknown. This study investigated the transcallosal WM structure and lower limb motor stability performance in adolescents aged 10–18 years with spastic hemiplegic (n=18) or diplegic (n=13) CP and in their age-matched controls (n=34). The modern difusion-weighted MRI analysis included the difusivity properties of seven CC subparts and the transcallosal lower limb sensorimotor tract of the dominant hemisphere. Children with CP had comprehensive impairments in the cross-sectional area, fractional anisotropy, and mean difusivity of the CC and sensorimotor tract. Additionally, the extent of WM alterations varied between hemiplegic and diplegic subgroups, which was seen especially in the fractional anisotropy values along the sensorimotor tract. The difusion properties of transcallosal WM were further associated with static stability in all groups, and with dynamic stability in healthy controls. Our novel results clarify the mechanistic role of the corpus callosum in adolescents with and without CP ofering valuable insight into the complex interplay between the brain’s WM organization and motor performance. A better understanding of the brain basis of weakened stability performance could, in addition, improve the specifcity of clinical diagnosis and targeted rehabilitation in CP.

YSO-asiasanat: CP-oireyhtymä; nuoret; aivot; valkea aine; motoriikka; motoriset taidot; tasapaino; häiriöt; kuvantaminen

Vapaat asiasanat: aivokurkiainen

Liittyvät organisaatiot

Hankkeet, joissa julkaisu on tehty

OKM-raportointi: Kyllä

Raportointivuosi: 2023

Alustava JUFO-taso: 1