A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Effect of a Multicomponent Intervention on Hepatic Steatosis Is Partially Mediated by the Reduction of Intermuscular Abdominal Adipose Tissue in Children With Overweight or Obesity : The EFIGRO Project (2022)
Cadenas-Sanchez, C., Idoate, F., Cabeza, R., Villanueva, A., Rodríguez-Vigil, B., Medrano, M., Osés, M., Ortega, F. B., Ruiz, J. R., & Labayen, I. (2022). Effect of a Multicomponent Intervention on Hepatic Steatosis Is Partially Mediated by the Reduction of Intermuscular Abdominal Adipose Tissue in Children With Overweight or Obesity : The EFIGRO Project. Diabetes Care, 45(9), 1953-1960. https://doi.org/10.2337/dc21-2440
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Cadenas-Sanchez, Cristina; Idoate, Fernando; Cabeza, Rafael; Villanueva, Arantxa; Rodríguez-Vigil, Beatriz; Medrano, María; Osés, Maddi; Ortega, Francisco B.; Ruiz, Jonatan R.; Labayen, Idoia
Lehti tai sarja: Diabetes Care
ISSN: 0149-5992
eISSN: 1935-5548
Julkaisuvuosi: 2022
Volyymi: 45
Lehden numero: 9
Artikkelin sivunumerot: 1953-1960
Kustantaja: American Diabetes Association
Julkaisumaa: Yhdysvallat (USA)
Julkaisun kieli: englanti
DOI: https://doi.org/10.2337/dc21-2440
Julkaisun avoin saatavuus: Muulla tavalla avoin
Julkaisukanavan avoin saatavuus:
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/89534
Tiivistelmä
In adults, there is evidence that improvement of metabolic-associated fatty liver disease (MAFLD) depends on the reduction of myosteatosis. In children, in whom the prevalence of MAFLD is alarming, this muscle-liver crosstalk has not been tested. Therefore, we aimed to explore whether the effects of a multicomponent intervention on hepatic fat is mediated by changes in intermuscular abdominal adipose tissue (IMAAT) in children with overweight/obesity.
RESEARCH DESIGN AND METHODS
A total of 116 children with overweight/obesity were allocated to a 22-week family-based lifestyle and psychoeducational intervention (control group, n = 57) or the same intervention plus supervised exercise (exercise group, n = 59). Hepatic fat percentage and IMAAT were acquired by MRI at baseline and at the end of the intervention.
RESULTS
Changes in IMAAT explained 20.7% of the improvements in hepatic steatosis (P < 0.05). Only children who meaningfully reduced their IMAAT (i.e., responders) had improved hepatic steatosis at the end of the intervention (within-group analysis: responders −20% [P = 0.005] vs. nonresponders −1.5% [P = 0.803]). Between-group analysis showed greater reductions in favor of IMAAT responders compared with nonresponders (18.3% vs. 0.6%, P = 0.018), regardless of overall abdominal fat loss.
CONCLUSIONS
The reduction of IMAAT plays a relevant role in the improvement of hepatic steatosis after a multicomponent intervention in children with overweight/obesity. Indeed, only children who achieved a meaningful reduction in IMAAT at the end of the intervention had a reduced percentage of hepatic fat independent of abdominal fat loss. Our findings suggest that abdominal muscle fat infiltration could be a therapeutic target for the treatment of MAFLD in childhood.
YSO-asiasanat: rasvamaksa; rasvakudokset; ylipaino; lihavuus; lapset (ikäryhmät)
Liittyvät organisaatiot
OKM-raportointi: Kyllä
VIRTA-lähetysvuosi: 2023
JUFO-taso: 2
