A2 Review article, Literature review, Systematic review
Active Gains in brain Using Exercise During Aging (AGUEDA) : protocol for a randomized controlled trial (2023)

Solis-Urra, P., Molina-Hidalgo, C., García-Rivero, Y., Costa-Rodriguez, C., Mora-Gonzalez, J., Fernandez-Gamez, B., Olvera-Rojas, M., Coca-Pulido, A., Toval, A., Bellón, D., Sclafani, A., Martín-Fuentes, I., Triviño-Ibañez, E. M., de Teresa, C., Huang, H., Grove, G., Hillman, C. H., Kramer, A. F., Catena, A., . . . Esteban-Cornejo, I. (2023). Active Gains in brain Using Exercise During Aging (AGUEDA) : protocol for a randomized controlled trial. Frontiers in Human Neuroscience, 17, Article 1168549. https://doi.org/10.3389/fnhum.2023.1168549

JYU authors or editors

Publication details

All authors or editorsSolis-Urra, Patricio; Molina-Hidalgo, Cristina; García-Rivero, Yolanda; Costa-Rodriguez, Claudia; Mora-Gonzalez, Jose; Fernandez-Gamez, Beatriz; Olvera-Rojas, Marcos; Coca-Pulido, Andrea; Toval, Angel; Bellón, Darío; et al.

Journal or seriesFrontiers in Human Neuroscience


Publication year2023

Publication date22/05/2023


Article number1168549

PublisherFrontiers Media

Publication countrySwitzerland

Publication languageEnglish


Publication open accessOpenly available

Publication channel open accessOpen Access channel

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/90585

Publication is parallel publishedhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239947/


Alzheimer’s disease is currently the leading cause of dementia and one of the most expensive, lethal and severe diseases worldwide. Age-related decline in executive function is widespread and plays a key role in subsequent dementia risk. Physical exercise has been proposed as one of the leading non-pharmaceutical approaches to improve executive function and ameliorate cognitive decline. This single-site, two-arm, single-blinded, randomized controlled trial (RCT) will include 90 cognitively normal older adults, aged 65–80 years old. Participants will be randomized to a 24-week resistance exercise program (3 sessions/week, 60 min/session, n = 45), or a wait-list control group (n = 45) which will be asked to maintain their usual lifestyle. All study outcomes will be assessed at baseline and at 24-weeks after the exercise program, with a subset of selected outcomes assessed at 12-weeks. The primary outcome will be indicated by the change in an executive function composite score assessed with a comprehensive neuropsychological battery and the National Institutes of Health Toolbox Cognition Battery. Secondary outcomes will include changes in brain structure and function and amyloid deposition, other cognitive outcomes, and changes in molecular biomarkers assessed in blood, saliva, and fecal samples, physical function, muscular strength, body composition, mental health, and psychosocial parameters. We expect that the resistance exercise program will have positive effects on executive function and related brain structure and function, and will help to understand the molecular, structural, functional, and psychosocial mechanisms involved.

Keywordsphysical trainingtrainingageingbrainAlzheimer's diseasedementiacognitive processesfunctional capacity

Free keywordsexercise; executive function; Alzheimer’s disease; amyloid beta; brain

Contributing organizations

Ministry reportingYes

Reporting Year2023

JUFO rating1

Last updated on 2024-15-05 at 13:24