A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Early growth, stress, and socioeconomic factors as predictors of the rate of multimorbidity accumulation across the life course : a longitudinal birth cohort study (2024)
Haapanen, M. J., Vetrano, D. L., Mikkola, T. M., Calderón-Larrañaga, A., Dekhtyar, S., Kajantie, E., Eriksson, J. G., & von Bonsdorff, M. B. (2024). Early growth, stress, and socioeconomic factors as predictors of the rate of multimorbidity accumulation across the life course : a longitudinal birth cohort study. Lancet Healthy Longevity, 5(1), e56-e65. https://doi.org/10.1016/S2666-7568(23)00231-3
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Haapanen, Markus J.; Vetrano, Davide L.; Mikkola, Tuija M.; Calderón-Larrañaga, Amaia; Dekhtyar, Serhiy; Kajantie, Eero; Eriksson, Johan G.; von Bonsdorff, Mikaela B.
Lehti tai sarja: Lancet Healthy Longevity
ISSN: 2666-7568
eISSN: 2666-7568
Julkaisuvuosi: 2024
Volyymi: 5
Lehden numero: 1
Artikkelin sivunumerot: e56-e65
Kustantaja: Elsevier
Julkaisumaa: Britannia
Julkaisun kieli: englanti
DOI: https://doi.org/10.1016/S2666-7568(23)00231-3
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/92426
Tiivistelmä
Early growth, stress, and socioeconomic factors are associated with future risk of individual chronic diseases. It is uncertain whether they also affect the rate of multimorbidity accumulation later in life. This study aimed to explore whether early life factors are associated with the rate at which chronic diseases are accumulated across older age.
Methods
In this national birth cohort study, we studied people born at Helsinki University Central Hospital, Helsinki, Finland between Jan 1, 1934, and Dec 31, 1944, who attended child welfare clinics in the city, and were living in Finland in 1971. Individuals who had died or emigrated from Finland before 1987 were excluded, alongside participants without any registry data and who died before the end of the registry follow-up on Dec 31, 2017. Early anthropometry, growth, wartime parental separation, and socioeconomic factors were recorded from birth, child welfare clinic, or school health-care records, and Finnish National Archives. International Classification of Diseases codes of diagnoses for chronic diseases were obtained from the Care Register for Health Care starting from 1987 (when participants were aged 42–53 years) until 2017. Linear mixed models were used to study the association between early-life factors and the rate of change in the number of chronic diseases over 10-year periods.
Findings
From Jan 1, 1934, to Dec 31, 2017, 11 689 people (6064 [51·9%] men and 5625 [48·1%] women) were included in the study. Individuals born to mothers younger than 25 years (β 0·09; 95% CI 0·06–0·12), mothers with a BMI of 25–30 kg/m2 (0·08; 0·05–0·10), and mothers with a BMI more than 30 kg/m2 (0·26; 0·21–0·31) in late pregnancy accumulated chronic diseases faster than those born to older mothers (25–30 years) and those with a BMI of less than 25 kg/m2. Individuals with a birthweight less than 2·5 kg (0·17; 0·10–0·25) and those with a rapid growth in height and weight from birth until age 11 years accumulated chronic diseases faster during their life course. Additionally, paternal occupational class (manual workers vs upper-middle class 0·27; 0·23–0·30) and wartime parental separation (0·24; 0·19–0·29 for boys; 0·31; 0·25–0·36 for girls) were associated with a faster rate of chronic disease accumulation.
Interpretation
Our findings suggest that the foundation for accumulating chronic diseases is established early in life. Early interventions might be needed for vulnerable populations, including war evacuee children and children with lower socioeconomic status.
YSO-asiasanat: krooniset taudit; sairaudet; sosioekonomiset tekijät; varhaislapsuus
Liittyvät organisaatiot
OKM-raportointi: Kyllä
VIRTA-lähetysvuosi: 2023
Alustava JUFO-taso: 1
