A1 Journal article (refereed)
Proteomic insights into mental health status : plasma markers in young adults (2024)

Afonin, A. M., Piironen, A.-K., de Sousa, M. I., Ivanova, M., Alatalo, A., Whipp, A. M., Pulkkinen, L., Rose, R. J., van Kamp, I., Kaprio, J., & Kanninen, K. M. (2024). Proteomic insights into mental health status : plasma markers in young adults. Translational Psychiatry, 14, Article 55. https://doi.org/10.1038/s41398-024-02751-z

JYU authors or editors

Publication details

All authors or editors: Afonin, Alexey M.; Piironen, Aino-Kaisa; de Sousa, Maciel Izaque; Ivanova, Mariia; Alatalo, Arto; Whipp, Alyce M.; Pulkkinen, Lea; Rose, Richard J.; van Kamp, Irene; Kaprio, Jaakko; et al.

Journal or series: Translational Psychiatry

eISSN: 2158-3188

Publication year: 2024

Publication date: 24/01/2024

Volume: 14

Article number: 55

Publisher: Nature Publishing Group

Publication country: United Kingdom

Publication language: English

DOI: https://doi.org/10.1038/s41398-024-02751-z

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/93185

Abstract

Global emphasis on enhancing prevention and treatment strategies necessitates an increased understanding of the biological mechanisms of psychopathology. Plasma proteomics is a powerful tool that has been applied in the context of specific mental disorders for biomarker identification. The p-factor, also known as the “general psychopathology factor”, is a concept in psychopathology suggesting that there is a common underlying factor that contributes to the development of various forms of mental disorders. It has been proposed that the p-factor can be used to understand the overall mental health status of an individual. Here, we aimed to discover plasma proteins associated with the p-factor in 775 young adults in the FinnTwin12 cohort. Using liquid chromatography–tandem mass spectrometry, 13 proteins with a significant connection with the p-factor were identified, 8 of which were linked to epidermal growth factor receptor (EGFR) signaling. This exploratory study provides new insight into biological alterations associated with mental health status in young adults.

Keywords: biomarkers; psychology; mental disorders; young adults

Free keywords: biomarkers; psychology

Contributing organizations

Ministry reporting: Yes

VIRTA submission year: 2024

Preliminary JUFO rating: 1