A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Circulating metabolome landscape in Lynch syndrome (2024)


Jokela, T. A., Karppinen, J. E., Kärkkäinen, M., Mecklin, J.-P., Walker, S., Seppälä, T. T., & Laakkonen, E. K. (2024). Circulating metabolome landscape in Lynch syndrome. Cancer and Metabolism, 12, Article 4. https://doi.org/10.1186/s40170-024-00331-9


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajatJokela, Tiina A.; Karppinen, Jari E.; Kärkkäinen, Minta; Mecklin, Jukka-Pekka; Walker, Simon; Seppälä, Toni T.; Laakkonen, Eija K.

Lehti tai sarjaCancer and Metabolism

eISSN2049-3002

Julkaisuvuosi2024

Ilmestymispäivä05.02.2024

Volyymi12

Artikkelinumero4

KustantajaBiomed Central

JulkaisumaaBritannia

Julkaisun kielienglanti

DOIhttps://doi.org/10.1186/s40170-024-00331-9

Julkaisun avoin saatavuusAvoimesti saatavilla

Julkaisukanavan avoin saatavuusOsittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX)https://jyx.jyu.fi/handle/123456789/93387


Tiivistelmä

Circulating metabolites systemically reflect cellular processes and can modulate the tissue microenvironment in complex ways, potentially impacting cancer initiation processes. Genetic background increases cancer risk in individuals with Lynch syndrome; however, not all carriers develop cancer. Various lifestyle factors can influence Lynch syndrome cancer risk, and lifestyle choices actively shape systemic metabolism, with circulating metabolites potentially serving as the mechanical link between lifestyle and cancer risk. This study aims to characterize the circulating metabolome of Lynch syndrome carriers, shedding light on the energy metabolism status in this cancer predisposition syndrome.

This study consists of a three-group cross-sectional analysis to compare the circulating metabolome of cancer-free Lynch syndrome carriers, sporadic colorectal cancer (CRC) patients, and healthy non-carrier controls. We detected elevated levels of circulating cholesterol, lipids, and lipoproteins in LS carriers. Furthermore, we unveiled that Lynch syndrome carriers and CRC patients displayed similar alterations compared to healthy non-carriers in circulating amino acid and ketone body profiles. Overall, cancer-free Lynch syndrome carriers showed a unique circulating metabolome landscape.

This study provides valuable insights into the systemic metabolic landscape of Lynch syndrome individuals. The findings hint at shared metabolic patterns between cancer-free Lynch syndrome carriers and CRC patients.


YSO-asiasanataineenvaihduntaaineenvaihduntahäiriötperinnölliset tauditsyöpätauditkolesteroli

Vapaat asiasanatmetabolomic biomarkers; DNA mismatch repair defciency; hereditary cancer; lipid metabolism; cholesterol metabolism; circulating amino acids; ketone bodies; GlycA


Liittyvät organisaatiot


Hankkeet, joissa julkaisu on tehty


OKM-raportointiKyllä

VIRTA-lähetysvuosi2024

Alustava JUFO-taso1


Viimeisin päivitys 2024-16-11 klo 20:06