A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Intrinsic running capacity associates with hippocampal electrophysiology and long-term potentiation in rats (2024)


Mäkinen, E. E., Lensu, S., Wikgren, J., Pekkala, S., Koch, L. G., Britton, S. L., & Nokia, M. S. (2024). Intrinsic running capacity associates with hippocampal electrophysiology and long-term potentiation in rats. Neuroscience Letters, 823, Article 137665. https://doi.org/10.1016/j.neulet.2024.137665


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajatMäkinen, Elina E.; Lensu, Sanna; Wikgren, Jan; Pekkala, Satu; Koch, Lauren G.; Britton, Steven L.; Nokia, Miriam S.

Lehti tai sarjaNeuroscience Letters

ISSN0304-3940

eISSN1872-7972

Julkaisuvuosi2024

Ilmestymispäivä30.01.2024

Volyymi823

Artikkelinumero137665

KustantajaElsevier

JulkaisumaaAlankomaat

Julkaisun kielienglanti

DOIhttps://doi.org/10.1016/j.neulet.2024.137665

Julkaisun avoin saatavuusEi avoin

Julkaisukanavan avoin saatavuus

Julkaisu on rinnakkaistallennettu (JYX)https://jyx.jyu.fi/handle/123456789/93981


Tiivistelmä

Good aerobic and metabolic fitness associates with better cognitive performance and brain health. Conversely, poor metabolic health predisposes to neurodegenerative diseases. Our previous findings indicate that rats selectively bred for Low Capacity for Running (LCR) show less synaptic plasticity and more inflammation in the hippocampus and perform worse in tasks requiring flexible cognition than rats bred for High Capacity for Running (HCR). Here we aimed to determine whether hippocampal electrophysiological activity related to learning and memory would be impaired in LCR compared to HCR rats. We also studied whether an exercise intervention could even out the possible differences. We conducted in vivo recordings from the dorsal hippocampus under terminal urethane anesthesia in middle-aged sedentary males and female rats, and in females allowed to access running wheels for 6 weeks. Our results indicate stronger long-term potentiation (LTP) in the CA3-CA1 synapse in HCR than LCR rats, and in female than male rats. Compared to LCR rats, HCR rats had more dentate spikes and more gamma epochs, the occurrence of which also correlated positively with the magnitude of LTP. Voluntary running reduced the differences between female LCR and HCR rats. In conclusion, low innate fitness links to reduced hippocampal function and plasticity which can seems to improve with voluntary aerobic exercise even in middle age.


YSO-asiasanatfyysinen kuntoaivothippokampuskognitiomuisti (kognitio)suorituskykyaerobinen harjoittelujuoksuelektrofysiologiaterveys

Vapaat asiasanatlong-term potentiation; electrophysiology; hippocampus; aerobic exercise capacity; voluntary running


Liittyvät organisaatiot


Hankkeet, joissa julkaisu on tehty


OKM-raportointiKyllä

Raportointivuosi2024

Alustava JUFO-taso1


Viimeisin päivitys 2024-13-05 klo 18:45