A2 Katsausartikkeli tieteellisessä aikausilehdessä
Effect of exercise for depression : systematic review and network meta-analysis of randomised controlled trials (2024)
Noetel, M., Sanders, T., Gallardo-Gómez, D., Taylor, P., del Pozo Cruz, B., van den Hoek, D., Smith, J. J., Mahoney, J., Spathis, J., Moresi, M., Pagano, R., Pagano, L., Vasconcellos, R., Arnott, H., Varley, B., Parker, P., Biddle, S., & Lonsdale, C. (2024). Effect of exercise for depression : systematic review and network meta-analysis of randomised controlled trials. BMJ, 384, Article e075847. https://doi.org/10.1136/bmj-2023-075847
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Noetel, Michael; Sanders, Taren; Gallardo-Gómez, Daniel; Taylor, Paul; del Pozo Cruz, Borja; van den Hoek, Daniel; Smith, Jordan J; Mahoney, John; Spathis, Jemima; Moresi, Mark; et al.
Lehti tai sarja: BMJ
ISSN: 0959-8138
eISSN: 1756-1833
Julkaisuvuosi: 2024
Ilmestymispäivä: 14.02.2024
Volyymi: 384
Artikkelinumero: e075847
Kustantaja: BMJ Publishing Group
Julkaisumaa: Britannia
Julkaisun kieli: englanti
DOI: https://doi.org/10.1136/bmj-2023-075847
Linkki tutkimusaineistoon: https://osf.io/nzw6u/
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/93572
Julkaisu on rinnakkaistallennettu: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10870815
Tiivistelmä
To identify the optimal dose and modality of exercise for treating major depressive disorder, compared with psychotherapy, antidepressants, and control conditions.
Design
Systematic review and network meta-analysis.
Methods
Screening, data extraction, coding, and risk of bias assessment were performed independently and in duplicate. Bayesian arm based, multilevel network meta-analyses were performed for the primary analyses. Quality of the evidence for each arm was graded using the confidence in network meta-analysis (CINeMA) online tool.
Data sources
Cochrane Library, Medline, Embase, SPORTDiscus, and PsycINFO databases.
Eligibility criteria for selecting studies
Any randomised trial with exercise arms for participants meeting clinical cut-offs for major depression.
Results
218 unique studies with a total of 495 arms and 14 170 participants were included. Compared with active controls (eg, usual care, placebo tablet), moderate reductions in depression were found for walking or jogging (n=1210, κ=51, Hedges’ g −0.62, 95% credible interval −0.80 to −0.45), yoga (n=1047, κ=33, g −0.55, −0.73 to −0.36), strength training (n=643, κ=22, g −0.49, −0.69 to −0.29), mixed aerobic exercises (n=1286, κ=51, g −0.43, −0.61 to −0.24), and tai chi or qigong (n=343, κ=12, g −0.42, −0.65 to −0.21). The effects of exercise were proportional to the intensity prescribed. Strength training and yoga appeared to be the most acceptable modalities. Results appeared robust to publication bias, but only one study met the Cochrane criteria for low risk of bias. As a result, confidence in accordance with CINeMA was low for walking or jogging and very low for other treatments.
Conclusions
Exercise is an effective treatment for depression, with walking or jogging, yoga, and strength training more effective than other exercises, particularly when intense. Yoga and strength training were well tolerated compared with other treatments. Exercise appeared equally effective for people with and without comorbidities and with different baseline levels of depression. To mitigate expectancy effects, future studies could aim to blind participants and staff. These forms of exercise could be considered alongside psychotherapy and antidepressants as core treatments for depression.
YSO-asiasanat: kuntoliikunta; harjoitukset; masennus; voimaharjoittelu; jooga; kävely; juoksu; systemaattiset kirjallisuuskatsaukset; meta-analyysi
Liittyvät organisaatiot
OKM-raportointi: Kyllä
VIRTA-lähetysvuosi: 2024
Alustava JUFO-taso: 2
