A2 Katsausartikkeli tieteellisessä aikausilehdessä
Effect of exercise for depression : systematic review and network meta-analysis of randomised controlled trials (2024)


Noetel, M., Sanders, T., Gallardo-Gómez, D., Taylor, P., del Pozo Cruz, B., van den Hoek, D., Smith, J. J., Mahoney, J., Spathis, J., Moresi, M., Pagano, R., Pagano, L., Vasconcellos, R., Arnott, H., Varley, B., Parker, P., Biddle, S., & Lonsdale, C. (2024). Effect of exercise for depression : systematic review and network meta-analysis of randomised controlled trials. BMJ, 384, Article e075847. https://doi.org/10.1136/bmj-2023-075847


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajatNoetel, Michael; Sanders, Taren; Gallardo-Gómez, Daniel; Taylor, Paul; del Pozo Cruz, Borja; van den Hoek, Daniel; Smith, Jordan J; Mahoney, John; Spathis, Jemima; Moresi, Mark; et al.

Lehti tai sarjaBMJ

ISSN0959-8138

eISSN1756-1833

Julkaisuvuosi2024

Ilmestymispäivä14.02.2024

Volyymi384

Artikkelinumeroe075847

KustantajaBMJ Publishing Group

JulkaisumaaBritannia

Julkaisun kielienglanti

DOIhttps://doi.org/10.1136/bmj-2023-075847

Linkki tutkimusaineistoonhttps://osf.io/nzw6u/

Julkaisun avoin saatavuusAvoimesti saatavilla

Julkaisukanavan avoin saatavuusKokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX)https://jyx.jyu.fi/handle/123456789/93572

Julkaisu on rinnakkaistallennettuhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10870815


Tiivistelmä

Objective
To identify the optimal dose and modality of exercise for treating major depressive disorder, compared with psychotherapy, antidepressants, and control conditions.

Design
Systematic review and network meta-analysis.

Methods
Screening, data extraction, coding, and risk of bias assessment were performed independently and in duplicate. Bayesian arm based, multilevel network meta-analyses were performed for the primary analyses. Quality of the evidence for each arm was graded using the confidence in network meta-analysis (CINeMA) online tool.

Data sources
Cochrane Library, Medline, Embase, SPORTDiscus, and PsycINFO databases.

Eligibility criteria for selecting studies
Any randomised trial with exercise arms for participants meeting clinical cut-offs for major depression.

Results
218 unique studies with a total of 495 arms and 14 170 participants were included. Compared with active controls (eg, usual care, placebo tablet), moderate reductions in depression were found for walking or jogging (n=1210, κ=51, Hedges’ g −0.62, 95% credible interval −0.80 to −0.45), yoga (n=1047, κ=33, g −0.55, −0.73 to −0.36), strength training (n=643, κ=22, g −0.49, −0.69 to −0.29), mixed aerobic exercises (n=1286, κ=51, g −0.43, −0.61 to −0.24), and tai chi or qigong (n=343, κ=12, g −0.42, −0.65 to −0.21). The effects of exercise were proportional to the intensity prescribed. Strength training and yoga appeared to be the most acceptable modalities. Results appeared robust to publication bias, but only one study met the Cochrane criteria for low risk of bias. As a result, confidence in accordance with CINeMA was low for walking or jogging and very low for other treatments.

Conclusions
Exercise is an effective treatment for depression, with walking or jogging, yoga, and strength training more effective than other exercises, particularly when intense. Yoga and strength training were well tolerated compared with other treatments. Exercise appeared equally effective for people with and without comorbidities and with different baseline levels of depression. To mitigate expectancy effects, future studies could aim to blind participants and staff. These forms of exercise could be considered alongside psychotherapy and antidepressants as core treatments for depression.


YSO-asiasanatkuntoliikuntaharjoituksetmasennusvoimaharjoittelujoogakävelyjuoksusystemaattiset kirjallisuuskatsauksetmeta-analyysi


Liittyvät organisaatiot


OKM-raportointiKyllä

Raportointivuosi2024

Alustava JUFO-taso2


Viimeisin päivitys 2024-13-05 klo 18:06