A1 Journal article (refereed)
Modifying the terminal phenyl group of monomethine cyanine dyes as a pathway to brighter nucleic acid probes (2024)


Alaranta, J. M., Valkonen, A. M., Shroff, S. S., Marjomäki, V. S., Rissanen, K., & Lahtinen, T. M. (2024). Modifying the terminal phenyl group of monomethine cyanine dyes as a pathway to brighter nucleic acid probes. New Journal of Chemistry, Advance Article. https://doi.org/10.1039/d3nj05400d


JYU authors or editors


Publication details

All authors or editors: Alaranta, Johanna M.; Valkonen, Arto M.; Shroff, Sailee S.; Marjomäki, Varpu S.; Rissanen, Kari; Lahtinen, Tanja M.

Journal or series: New Journal of Chemistry

ISSN: 1144-0546

eISSN: 1369-9261

Publication year: 2024

Publication date: 20/02/2024

Volume: Advance Article

Publisher: Royal Society of Chemistry (RSC)

Publication country: United Kingdom

Publication language: English

DOI: https://doi.org/10.1039/d3nj05400d

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/93826


Abstract

Three novel monomethine cyanine dyes were synthesized carrying electron donating groups to obtain
even brighter nucleic acids probes. Photophysical properties of these dyes were evaluated with DNA and
selected dyes with RNA. A great variation in brightness and binding properties of the dyes was observed.
Moreover the X-ray crystal structures are presented for two dyes.


Keywords: nucleic acids; tracers (indicators); colouring agents; gene technology


Contributing organizations


Related projects


Ministry reporting: Yes

VIRTA submission year: 2024

Preliminary JUFO rating: 1


Last updated on 2024-03-07 at 20:46