A2 Katsausartikkeli tieteellisessä aikausilehdessä
Early-life environmental effects on birds : epigenetics and microbiome as mechanisms underlying long-lasting phenotypic changes (2024)

Ruuskanen, S. (2024). Early-life environmental effects on birds : epigenetics and microbiome as mechanisms underlying long-lasting phenotypic changes. Journal of Experimental Biology, 227(Suppl_1), Article jeb246024. https://doi.org/10.1242/jeb.246024

JYU-tekijät tai -toimittajat

Ruuskanen, Suvi

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Ruuskanen, Suvi

Lehti tai sarja: Journal of Experimental Biology

ISSN: 0022-0949

eISSN: 1477-9145

Julkaisuvuosi: 2024

Ilmestymispäivä: 07.03.2024

Volyymi: 227

Lehden numero: Suppl_1

Artikkelinumero: jeb246024

Kustantaja: The Company of Biologists

Julkaisumaa: Britannia

Julkaisun kieli: englanti

DOI: https://doi.org/10.1242/jeb.246024

Julkaisun avoin saatavuus: Ei avoin

Julkaisukanavan avoin saatavuus: 

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/96495

Tiivistelmä

Although the long-lasting effects of variation in early-life environment have been well documented across organisms, the underlying causal mechanisms are only recently starting to be unraveled. Yet understanding the underlying mechanisms of long-lasting effects can help us predict how organisms will respond to changing environments. Birds offer a great system in which to study developmental plasticity and its underlying mechanisms owing to the production of large external eggs and variation in developmental trajectories, combined with a long tradition of applied, physiological, ecological and evolutionary research. Epigenetic changes (such as DNA methylation) have been suggested to be a key mechanism mediating long-lasting effects of the early-life environment across taxa. More recently, changes in the early-life gut microbiome have been identified as another potential mediator of developmental plasticity. As a first step in understanding whether these mechanisms contribute to developmental plasticity in birds, this Review summarizes how changes in early-life environment (both prenatal and postnatal) influence epigenetic markers and the gut microbiome. The literature shows how both early-life biotic (such as resources and social environment) and abiotic (thermal environment and various anthropogenic stressors) factors modify epigenetic markers and the gut microbiome in birds, yet data concerning many other environmental factors are limited. The causal links of these modifications to lasting phenotypic changes are still scarce, but changes in the hypothalamic–pituitary–adrenal axis have been identified as one putative pathway. This Review identifies several knowledge gaps, including data on the long-term effects, stability of the molecular changes, and lack of diversity in the systems studied, and provides directions for future research.

YSO-asiasanat: linnut; fenotyyppi; ympäristötekijät; epigenetiikka; DNA-metylaatio; suolistomikrobisto; kehitysbiologia

Vapaat asiasanat: developmental plasticity; early-life environment; DNA methylation; gut microbiome; Avian; developmental programming

Liittyvät organisaatiot

Hankkeet, joissa julkaisu on tehty

OKM-raportointi: Kyllä

VIRTA-lähetysvuosi: 2024

Alustava JUFO-taso: 2