A1 Journal article (refereed)
Cardiorespiratory rhythm-contingent trace eyeblink conditioning in elderly adults (2024)


Santhana Gopalan, P. R., Xu, W., Waselius, T., Wikgren, J., Penttonen, M., & Nokia, M. S. (2024). Cardiorespiratory rhythm-contingent trace eyeblink conditioning in elderly adults. Journal of Neurophysiology, 131(5), 797-806. https://doi.org/10.1152/jn.00356.2023


JYU authors or editors


Publication details

All authors or editorsSanthana Gopalan, Praghajieeth Raajhen; Xu, Weiyong; Waselius, Tomi; Wikgren, Jan; Penttonen, Markku; Nokia, Miriam S.

Journal or seriesJournal of Neurophysiology

ISSN0022-3077

eISSN1522-1598

Publication year2024

Publication date27/03/2024

Volume131

Issue number5

Pages range797-806

PublisherAmerican Physiological Society

Publication countryUnited States

Publication languageEnglish

DOIhttps://doi.org/10.1152/jn.00356.2023

Publication open accessNot open

Publication channel open access

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/94508


Abstract

Learning outcome is modified by the degree to which the subject responds and pays attention to specific stimuli. Our recent research suggests that presenting stimuli in contingency with a specific phase of the cardiorespiratory rhythm might expedite learning. Specifically, expiration-diastole (EXP-DIA) is beneficial for learning trace eyeblink conditioning (TEBC) compared to inspiration-systole (INS-SYS) in healthy young adults. The aim of this study was to investigate whether the same holds true in healthy elderly adults (n = 50, aged >70 years). Participants were instructed to watch a silent nature film while TEBC trials were presented either at INS-SYS or EXP-DIA (separate groups). Learned responses were determined as eyeblinks occurring after the tone-conditioned stimulus (CS), immediately preceding the airpuff-unconditioned stimulus (US). Participants were classified as learners if they made at least five conditioned responses (CRs). Brain responses to the stimuli were measured using electroencephalogram (EEG). Memory for the film and awareness of the CS-US contingency were evaluated with questionnaires. As a result, participants showed robust brain responses to the CS, acquired CRs, and reported awareness of the CS-US relationship to a variable degree. There was no difference between the INS-SYS and EXP-DIA groups in any of the above. However, when only participants who learned were considered, those trained at EXP-DIA (n=11) made more CRs than those trained at INS-SYS (n=13). Thus, learned performance could be facilitated in those elderly who learned. However, training at a specific phase of cardiorespiratory rhythm did not increase the proportion of participants who learned.


Keywordslearningconditioning (passive)respirationolder peopleneurophysiology

Free keywordslearning; heartbeat; respiration; ageing


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Ministry reportingYes

Reporting Year2024

Preliminary JUFO rating2


Last updated on 2024-13-05 at 18:26