A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
SoftVoting6mA : An improved ensemble-based method for predicting DNA N6-methyladenine sites in cross-species genomes (2024)
Yin, Z., Lyu, J., Zhang, G., Huang, X., Ma, Q., & Jiang, J. (2024). SoftVoting6mA : An improved ensemble-based method for predicting DNA N6-methyladenine sites in cross-species genomes. Mathematical Biosciences and Engineering, 21(3), 3798-3815. https://doi.org/10.3934/mbe.2024169
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Yin, Zhaoting; Lyu, Jianyi; Zhang, Guiyang; Huang, Xiaohong; Ma, Qinghua; Jiang, Jinyun
Lehti tai sarja: Mathematical Biosciences and Engineering
ISSN: 1547-1063
eISSN: 1551-0018
Julkaisuvuosi: 2024
Ilmestymispäivä: 19.02.2024
Volyymi: 21
Lehden numero: 3
Artikkelin sivunumerot: 3798-3815
Kustantaja: American Institute of Mathematical Sciences
Julkaisumaa: Yhdysvallat (USA)
Julkaisun kieli: englanti
DOI: https://doi.org/10.3934/mbe.2024169
Linkki tutkimusaineistoon: https://github.com/yinzhaoting/Softvoting-6mA
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava
Tiivistelmä
The DNA N6-methyladenine (6mA) is an epigenetic modification, which plays a pivotal role in biological processes encompassing gene expression, DNA replication, repair, and recombination. Therefore, the precise identification of 6mA sites is fundamental for better understanding its function, but challenging. We proposed an improved ensemble-based method for predicting DNA N6-methyladenine sites in cross-species genomes called SoftVoting6mA. The SoftVoting6mA selected four (electron–ion-interaction pseudo potential, One-hot encoding, Kmer, and pseudo dinucleotide composition) codes from 15 types of encoding to represent DNA sequences by comparing their performances. Similarly, the SoftVoting6mA combined four learning algorithms using the soft voting strategy. The 5-fold cross-validation and the independent tests showed that SoftVoting6mA reached the state-of-the-art performance. To enhance accessibility, a user-friendly web server is provided at http://www.biolscience.cn/SoftVoting6mA/.
YSO-asiasanat: DNA; geeniekspressio; koneoppiminen; neuroverkot; palvelimet; bioinformatiikka
Vapaat asiasanat: DNA N6-methyladenine; convolution neural network; soft voting; cross-species; feature fusion; webserver
Liittyvät organisaatiot
OKM-raportointi: Kyllä
Alustava JUFO-taso: 1